Abstract：
In SARSCoV-2 infections, excessive activation of the immune system dramatically elevates reactive oxygen species levels, harms cell structures, and directly increases disease severity and mortality. We aimed to evaluate whether plasma oxidative stress biomarker levels could predict mortality in adults admitted with Coronavirus Disease 2019 (COVID-19), considering potential confounders. We conducted a cohort study of 115 adults (62.1 ± 17.6 years, 65 males) admitted to a Brazilian public hospital for severely symptomatic COVID-19. Serum levels of α-tocopherol, glutathione, superoxide dismutase, 8-hydroxy-2\'-deoxyguanosine, malondialdehyde, and advanced oxidation protein products were quantified at COVID-19 diagnosis using real-time polymerase chain reaction. Serum levels of α-tocopherol, glutathione, superoxide dismutase, and advanced oxidation protein products differed significantly between survivors and non-survivors. Serum glutathione levels below 327.2 μmol/mL were associated with a significant risk of death in COVID-19 patients, even after accounting for other factors (adjusted hazard ratio = 3.12 [95% CI: 1.83-5.33]).
摘要：
在SARSCoV-2感染中，免疫系统的过度激活会显著提高活性氧水平，伤害细胞结构，并直接增加疾病的严重程度和死亡率。我们的目的是评估血浆氧化应激生物标志物水平是否可以预测2019年冠状病毒病(COVID-19)成年人的死亡率，考虑到潜在的混杂因素。我们对115名成年人进行了一项队列研究（62.1±17.6岁，65名男性)因症状严重的COVID-19入院巴西公立医院。血清α-生育酚水平,谷胱甘肽,超氧化物歧化酶,8-羟基-2'-脱氧鸟苷，丙二醛，和晚期氧化蛋白产物在COVID-19诊断时使用实时聚合酶链反应进行定量。血清α-生育酚水平,谷胱甘肽,超氧化物歧化酶,晚期氧化蛋白产物在幸存者和非幸存者之间存在显着差异。血清谷胱甘肽水平低于327.2μmol/mL与COVID-19患者的显著死亡风险相关，即使考虑了其他因素(调整后的风险比=3.12[95%CI:1.83-5.33])。
