Abstract：
Neurological diseases place a substantial burden on public health and have a serious impact on the quality of life of patients. Despite the multifaceted pathological process involved in the occurrence and development of these neurological diseases, each disease has its own unique pathological characteristics and underlying molecular mechanisms which trigger their onset. Thus, it is unlikely to achieve effective treatment of neurological diseases by means of a single approach. To this end, we reason that it is pivotal to seek an efficient strategy that implements multitherapeutic targeting and addresses the multifaceted pathological process to overcome the complex issues related to neural dysfunction. In recent years, natural medicinal plant-derived monomers have received extensive attention as new neuroprotective agents for treatment of neurological disorders. Fisetin, a flavonoid, has emerged as a novel potential molecule that enhances neural protection and reverses cognitive abnormalities. The neuroprotective effects of fisetin are attributed to its multifaceted biological activity and multiple therapeutic mechanisms associated with different neurological disorders. In this review article, we summarize recent research progression regarding the pharmacological effects of fisetin in treating several neurological diseases and the potential mechanisms.
摘要：
神经系统疾病对公共卫生造成沉重负担，严重影响患者的生活质量。尽管这些神经系统疾病的发生和发展涉及多方面的病理过程,每种疾病都有其独特的病理特征和引发其发病的潜在分子机制。因此，通过单一方法不太可能实现对神经系统疾病的有效治疗。为此,我们认为，寻求一种有效的策略来实现多治疗靶向并解决多方面的病理过程，以克服与神经功能障碍相关的复杂问题至关重要。近年来,天然药用植物来源的单体作为治疗神经系统疾病的新型神经保护剂已受到广泛关注。Fisetin,一种类黄酮，已经成为一种新型的潜在分子，可以增强神经保护并逆转认知异常。非塞素的神经保护作用归因于其多方面的生物活性和与不同神经系统疾病相关的多种治疗机制。在这篇评论文章中，本文就非塞素治疗多种神经系统疾病的药理作用及其潜在机制的研究进展作一综述。
