Abstract：
OBJECTIVE: To examine the risk of anxiety disorders in offspring of parents with mood disorders.
METHODS: We conducted a systematic review and meta-analysis. We searched 4 electronic databases (Medline, Embase, PsycINFO, and Web of Science [core collection]) to identify cross-sectional and cohort studies that examined the association between parental mood disorders (including bipolar disorder and unipolar depression) and risk of anxiety disorders in offspring. Pooled risk ratios (RRs) of overall and specific anxiety disorders were synthesized using a random effects model. Subgroup analyses and meta-regression were performed to identify moderation factors.
RESULTS: A total of 35 studies were included in the final analysis. Our results showed higher risks of all types of anxiety disorders in the offspring of parents with mood disorders (any anxiety disorder, RR = 1.82, 95% CI = 1.47-2.26), except for agoraphobia (RR = 1.08, 95% CI = 0.56-2.08), and with an especially elevated risk of panic disorder (RR = 3.07, 95% CI = 2.19-4.32). Subgroup analysis demonstrated no significant difference between the risks of anxiety disorders across the offspring of parents with bipolar disorder as opposed to unipolar depression. The absence of anxiety disorders in control parents, younger offspring age, and specific parent/offspring sex were associated with higher RRs for some anxiety disorders in offspring of parents with mood disorders.
CONCLUSIONS: Our findings suggest a robust relationship between parental mood disorders and offspring anxiety disorders, and highlight the potential value of prevention and early intervention for anxiety disorders in this context.
UNASSIGNED: We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. While citing references scientifically relevant for this work, we also actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our reference list.
UNASSIGNED: Anxiety Disorders in Offspring of Parents with Mood Disorders: A Systematic Review; https://www.crd.york.ac.uk/prospero/; CRD42021215058.
METHODS: We conducted a systematic review and meta-analysis. We searched 4 electronic databases (Medline, Embase, PsycINFO, and Web of Science [core collection]) to identify cross-sectional and cohort studies that examined the association between parental mood disorders (including bipolar disorder and unipolar depression) and risk of anxiety disorders in offspring. Pooled risk ratios (RRs) of overall and specific anxiety disorders were synthesized using a random effects model. Subgroup analyses and meta-regression were performed to identify moderation factors.
RESULTS: A total of 35 studies were included in the final analysis. Our results showed higher risks of all types of anxiety disorders in the offspring of parents with mood disorders (any anxiety disorder, RR = 1.82, 95% CI = 1.47-2.26), except for agoraphobia (RR = 1.08, 95% CI = 0.56-2.08), and with an especially elevated risk of panic disorder (RR = 3.07, 95% CI = 2.19-4.32). Subgroup analysis demonstrated no significant difference between the risks of anxiety disorders across the offspring of parents with bipolar disorder as opposed to unipolar depression. The absence of anxiety disorders in control parents, younger offspring age, and specific parent/offspring sex were associated with higher RRs for some anxiety disorders in offspring of parents with mood disorders.
CONCLUSIONS: Our findings suggest a robust relationship between parental mood disorders and offspring anxiety disorders, and highlight the potential value of prevention and early intervention for anxiety disorders in this context.
UNASSIGNED: We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. While citing references scientifically relevant for this work, we also actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our reference list.
UNASSIGNED: Anxiety Disorders in Offspring of Parents with Mood Disorders: A Systematic Review; https://www.crd.york.ac.uk/prospero/; CRD42021215058.
摘要：
目的：研究父母有情绪障碍的后代患焦虑症的风险。方法：我们进行了系统评价和荟萃分析。我们搜索了四个电子数据库-Medline,Embase,PsycINFO和WebofScience（核心集合）确定横断面和队列研究，这些研究检查了父母情绪障碍（包括双相情感障碍和单相抑郁症）与后代焦虑症风险之间的关联。使用随机效应模型合成总体和特定焦虑症的集合风险比（RR）。进行亚组分析和荟萃回归以确定调节因素。
结果：35项研究纳入最终分析。我们的结果表明，在患有情绪障碍的父母的后代中，所有类型的焦虑症的风险更高（任何焦虑症，RR=1.82，95%CI=1.47-2.26)，除了广场恐惧症（RR=1.08，0.56-2.08），并且恐慌症的风险特别高（RR=3.07，2.19-4.32）。亚组分析表明，与单相抑郁症相比，患有双相情感障碍的父母后代的焦虑症风险之间没有显着差异。控制父母没有焦虑症，在患有情绪障碍的父母的后代中,较年轻的后代年龄和特定的父母/后代性别与较高的RRs相关。
结论：我们的研究结果表明父母情绪障碍和后代焦虑症之间存在密切的关系，并强调了在这种情况下预防和早期干预焦虑症的潜在价值。
结果：35项研究纳入最终分析。我们的结果表明，在患有情绪障碍的父母的后代中，所有类型的焦虑症的风险更高（任何焦虑症，RR=1.82，95%CI=1.47-2.26)，除了广场恐惧症（RR=1.08，0.56-2.08），并且恐慌症的风险特别高（RR=3.07，2.19-4.32）。亚组分析表明，与单相抑郁症相比，患有双相情感障碍的父母后代的焦虑症风险之间没有显着差异。控制父母没有焦虑症，在患有情绪障碍的父母的后代中,较年轻的后代年龄和特定的父母/后代性别与较高的RRs相关。
结论：我们的研究结果表明父母情绪障碍和后代焦虑症之间存在密切的关系，并强调了在这种情况下预防和早期干预焦虑症的潜在价值。
