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Abstract：
BACKGROUND: The prevalence and clinical characteristics of different etiologies of peripheral edema in dogs are unknown.
OBJECTIVE: To determine the prevalence of different etiologies of peripheral edema, describe clinical characteristics that vary among etiologies, and report survival times.
METHODS: Five hundred twenty-seven dogs with peripheral edema.
METHODS: Retrospective medical record review. Differences in clinical variables among etiology groups were assessed by Kruskal-Wallis testing with post hoc pairwise Dunn\'s testing and Chi-square testing with Monte Carlo simulation.
RESULTS: The most common etiologies of peripheral edema in dogs were vasculitis (n = 193, 37%), lymphatic/venous obstruction (LVO; 114, 22%), and hypoalbuminemia (94, 18%). Right-sided congestive heart failure (R-CHF) was uncommon (25, 5%). Edema was localized in 377 (72%) dogs and generalized in 142 (27%) dogs, and hypoalbuminemia was more likely to cause generalized edema compared to LVO or vasculitis (P < .0001). Concurrent abdominal effusion (155, 29%) was more common than pleural (77, 15%) or pericardial (12, 2%) effusion. Abdominal and pleural effusion occurred more commonly in dogs with hypoalbuminemia or R-CHF compared to LVO or vasculitis (P < .0001).
CONCLUSIONS: Distribution of edema, concurrent cavitary effusions, and clinicopathological data can help predict the underlying etiology of peripheral edema in dogs.
OBJECTIVE: To determine the prevalence of different etiologies of peripheral edema, describe clinical characteristics that vary among etiologies, and report survival times.
METHODS: Five hundred twenty-seven dogs with peripheral edema.
METHODS: Retrospective medical record review. Differences in clinical variables among etiology groups were assessed by Kruskal-Wallis testing with post hoc pairwise Dunn\'s testing and Chi-square testing with Monte Carlo simulation.
RESULTS: The most common etiologies of peripheral edema in dogs were vasculitis (n = 193, 37%), lymphatic/venous obstruction (LVO; 114, 22%), and hypoalbuminemia (94, 18%). Right-sided congestive heart failure (R-CHF) was uncommon (25, 5%). Edema was localized in 377 (72%) dogs and generalized in 142 (27%) dogs, and hypoalbuminemia was more likely to cause generalized edema compared to LVO or vasculitis (P < .0001). Concurrent abdominal effusion (155, 29%) was more common than pleural (77, 15%) or pericardial (12, 2%) effusion. Abdominal and pleural effusion occurred more commonly in dogs with hypoalbuminemia or R-CHF compared to LVO or vasculitis (P < .0001).
CONCLUSIONS: Distribution of edema, concurrent cavitary effusions, and clinicopathological data can help predict the underlying etiology of peripheral edema in dogs.
摘要：
背景：犬外周水肿的不同病因的患病率和临床特征尚不清楚。
目的：为了确定周围水肿的不同病因的患病率，描述不同病因的临床特征，并报告生存时间。
方法：有外周水肿的五百二十七只狗。
方法：回顾性病历回顾。病因学组之间临床变量的差异通过Kruskal-Wallis检验，事后成对Dunn检验和卡方检验与蒙特卡洛模拟评估。
结果：狗周围性水肿最常见的病因是血管炎（n=193，37％），淋巴/静脉阻塞（LVO;114，22％），和低蛋白血症（94，18％）。右侧充血性心力衰竭（R-CHF）并不常见（25，5％）。水肿在377只（72％）狗中局部化，在142只（27％）狗中广泛化。与LVO或血管炎相比，低白蛋白血症更容易引起全身水肿（P<0.0001）。并发腹腔积液（155，29％）比胸膜积液（77，15％）或心包积液（12，2％）更常见。与LVO或血管炎相比，低白蛋白血症或R-CHF犬的腹腔和胸腔积液更常见（P<0.0001）。
结论：水肿的分布，并发空洞积液，和临床病理数据可以帮助预测狗周围水肿的潜在病因。
目的：为了确定周围水肿的不同病因的患病率，描述不同病因的临床特征，并报告生存时间。
方法：有外周水肿的五百二十七只狗。
方法：回顾性病历回顾。病因学组之间临床变量的差异通过Kruskal-Wallis检验，事后成对Dunn检验和卡方检验与蒙特卡洛模拟评估。
结果：狗周围性水肿最常见的病因是血管炎（n=193，37％），淋巴/静脉阻塞（LVO;114，22％），和低蛋白血症（94，18％）。右侧充血性心力衰竭（R-CHF）并不常见（25，5％）。水肿在377只（72％）狗中局部化，在142只（27％）狗中广泛化。与LVO或血管炎相比，低白蛋白血症更容易引起全身水肿（P<0.0001）。并发腹腔积液（155，29％）比胸膜积液（77，15％）或心包积液（12，2％）更常见。与LVO或血管炎相比，低白蛋白血症或R-CHF犬的腹腔和胸腔积液更常见（P<0.0001）。
结论：水肿的分布，并发空洞积液，和临床病理数据可以帮助预测狗周围水肿的潜在病因。
