PDF(Pubmed)
Abstract：
Methamphetamine (MAP) is a highly addictive and illegal stimulant drug that has a significant impact on the central nervous system. Its detection in biological and street samples is crucial for various organizations involved in forensic medicine, anti-drug efforts, and clinical diagnosis. In recent years, nanotechnology and nanomaterials have played a significant role in the development of analytical sensors for MAP detection. In this study, a fast, simple, and cost-effective electrochemical sensor is presented that is used for the sensitive detection of MAP in confiscated street samples with a complex matrix. The optimized screen-printed sensor based on a carbon working electrode modified with graphene demonstrated an excellent limit of detection, good sensitivity, and a wide dynamic range (1-500 μM) for the target illicit drug both for standard solutions and real samples (seized samples, tap water, and wastewater samples). It can detect MAP at concentrations as low as 300 nM in real samples. This limit of detection is suitable for the rapid preliminary screening of suspicious samples in customs, ports, airports, and on the street. Furthermore, the sensor exhibits a good recovery rate, indicating its reliability and repeatability. This quality is crucial for ensuring consistent and accurate results during screening processes.
摘要：
甲基苯丙胺（MAP）是一种高度成瘾性和非法的兴奋剂药物，对中枢神经体系有显著影响。它在生物和街头样本中的检测对于参与法医学的各种组织至关重要，禁毒努力，和临床诊断。近年来,纳米技术和纳米材料在MAP检测分析传感器的开发中发挥了重要作用。在这项研究中,一个快速的，简单,提出了具有成本效益的电化学传感器，用于在具有复杂基质的没收街道样品中对MAP进行灵敏检测。基于石墨烯修饰的碳工作电极的优化的丝网印刷传感器表现出优异的检测极限，灵敏度好,对于标准溶液和真实样品（缉获的样品，自来水,和废水样品)。它可以检测MAP浓度低至300nM的真实样品。这一检测限适用于海关对可疑样品的快速初筛,端口,机场,在街上。此外，传感器表现出良好的回收率，表明其可靠性和可重复性。这种质量对于确保筛选过程中一致和准确的结果至关重要。
