PDF(Pubmed)
Abstract：
Skeletal muscle is essential for human locomotion as well as maintaining metabolic homeostasis. Age-related reduction in skeletal muscle mass, strength, and function (i.e., sarcopenia) is a result of pathophysiological processes that include inflammation, alteration of molecular signaling for muscle protein synthesis and degradation, changes in insulin sensitivity, as well as altered skeletal muscle satellite cell activity. Finding strategies to mitigate skeletal muscle loss with age is deemed paramount as the percentage of the population continues to shift towards having more older adults with sarcopenia. Recent research indicates omega-3 fatty acid supplementation can influence anabolic or catabolic pathways in skeletal muscle. Our brief review will provide a synopsis of some underlying mechanisms that may be attributed to omega-3 fatty acid supplementation\'s effects on skeletal muscle. We will approach this review by focusing on cell culture, animal (pre-clinical models), and human studies evaluating omega-3 fatty acid supplementation, with suggestions for future research. In older adults, omega-3 fatty acids may possess some potential to modify pathophysiological pathways associated with sarcopenia; however, it is highly likely that omega-3 fatty acids need to be combined with other anabolic interventions to effectively ameliorate sarcopenia.
摘要：
骨骼肌对于人类运动以及维持代谢稳态是必不可少的。与年龄相关的骨骼肌质量减少，力量,和函数(即，肌肉减少症）是包括炎症在内的病理生理过程的结果，肌肉蛋白质合成和降解的分子信号改变，胰岛素敏感性的变化，以及骨骼肌卫星细胞活性的改变.随着年龄的增长，寻找减轻骨骼肌损失的策略被认为是至关重要的，因为人口的百分比继续转向更多的老年人患有肌肉减少症。最近的研究表明补充omega-3脂肪酸可以影响骨骼肌中的合成代谢或分解代谢途径。我们的简要综述将提供一些可能归因于补充omega-3脂肪酸对骨骼肌影响的潜在机制的概要。我们将通过关注细胞培养来进行这篇综述，动物（临床前模型），和人体研究评估补充omega-3脂肪酸，对未来的研究提出了建议。在老年人中,omega-3脂肪酸可能具有改变与肌肉减少症相关的病理生理途径的潜力；然而，omega-3脂肪酸很可能需要与其他合成代谢干预措施结合使用以有效改善肌肉减少症.
