PDF(Pubmed)
Abstract：
Hypertension is one of the most significant risk factors for many cardiovascular diseases. At different stages of hypertension development, various pathophysiological processes can play a key role in the manifestation of the hypertensive phenotype and of comorbid conditions. Accordingly, it is thought that when diagnosing and choosing a strategy for treating hypertension, it is necessary to take into account age, the stage of disorder development, comorbidities, and effects of emotional-psychosocial factors. Nonetheless, such an approach to choosing a treatment strategy is hampered by incomplete knowledge about details of age-related associations between the numerous features that may contribute to the manifestation of the hypertensive phenotype. Here, we used two groups of male F2(ISIAHxWAG) hybrids of different ages, obtained by crossing hypertensive ISIAH rats (simulating stress-sensitive arterial hypertension) and normotensive WAG rats. By principal component analysis, the relationships among 21 morphological, physiological, and behavioral traits were examined. It was shown that the development of stress-sensitive hypertension in ISIAH rats is accompanied not only by an age-dependent (FDR < 5%) persistent increase in basal blood pressure but also by a decrease in the response to stress and by an increase in anxiety. The plasma corticosterone concentration at rest and its increase during short-term restraint stress in a group of young rats did not have a straightforward relationship with the other analyzed traits. Nonetheless, in older animals, such associations were found. Thus, the study revealed age-dependent relationships between the key features that determine hypertension manifestation in ISIAH rats. Our results may be useful for designing therapeutic strategies against stress-sensitive hypertension, taking into account the patients\' age.
摘要：
高血压是许多心血管疾病最重要的危险因素之一。在高血压发展的不同阶段，各种病理生理过程在高血压表型和合并症的表现中可以发挥关键作用。因此，人们认为，在诊断和选择治疗高血压的策略时，有必要考虑年龄，无序发展的阶段，合并症,以及情绪-心理社会因素的影响。尽管如此，这种选择治疗策略的方法由于对可能导致高血压表型表现的众多特征之间年龄相关关联的详细信息的了解不完全而受到阻碍.这里,我们使用了两组不同年龄的雄性F2（ISIAHxWAG）杂种，通过将高血压ISIAH大鼠（模拟应激敏感性动脉高血压）和正常血压WAG大鼠交叉获得。通过主成分分析，21种形态学，生理,并检查了行为特征。研究表明，ISIAH大鼠中压力敏感性高血压的发展不仅伴随着年龄依赖性（FDR<5％）基础血压的持续升高，而且伴随着对压力的反应降低和焦虑的增加。一组年轻大鼠在休息时的血浆皮质酮浓度及其在短期束缚应激期间的增加与其他分析的性状没有直接的关系。尽管如此，在年长的动物中，发现了这样的关联。因此，该研究揭示了决定ISIAH大鼠高血压表现的关键特征之间的年龄依赖性关系.我们的结果可能有助于设计针对压力敏感性高血压的治疗策略，考虑到病人的年龄。
