Abstract：
This study aimed to evaluate the scientific literature on the micronucleus assay in nasal mucosa as an appropriate method for evaluating genotoxicity caused by chemical agents. According to the PRISMA guidelines, only in vivo human studies with micronucleus assays using nasal cells were considered. Reviews, case reports, editorials, letters to the editor, and articles not written in English were excluded. The following scientific databases/search engines were used: PubMed/MEDLINE, Scopus, and Web of Science. Results: This review included 13 studies. Four articles detected no statistical significance regarding the frequency of micronuclei while nine articles showed an increase in micronuclei in nasal cells. In the qualitative analysis, two articles were considered strong, eight were moderate and three were weak. The micronucleus assay using nasal mucosa cells is a sensitive and effective technique for assessing DNA damage and an appropriate method for monitoring humans continuously exposed to chemicals.
摘要：
本研究旨在评估有关鼻粘膜微核试验的科学文献，作为评估化学试剂引起的遗传毒性的适当方法。根据PRISMA指南,仅考虑了使用鼻细胞进行微核试验的体内人体研究。评论,病例报告,社论,给编辑的信，非英文文章被排除在外。使用了以下科学数据库/搜索引擎：PubMed/MEDLINE，Scopus,和WebofScience。结果：本综述包括13项研究。四篇文章在微核频率方面没有发现统计学意义，而九篇文章显示鼻细胞中的微核增加。在定性分析中,两篇文章被认为是强有力的，八个是中度的，三个是虚弱的。使用鼻粘膜细胞的微核试验是评估DNA损伤的灵敏有效技术，也是监测连续暴露于化学物质的人类的适当方法。
