PDF(Pubmed)
Abstract：
Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and receptor molecules, is a relevant component of structure-function relationships in the human brain. Here, we studied the organization of the receptome, a measure of interareal chemoarchitectural similarity, derived from positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors. Nonlinear dimensionality reduction revealed three main spatial gradients of cortical chemoarchitectural similarity - a centro-temporal gradient, an occipito-frontal gradient, and a temporo-occipital gradient. In subcortical nuclei, chemoarchitectural similarity distinguished functional communities and delineated a striato-thalamic axis. Overall, the cortical receptome shared key organizational traits with functional and structural brain anatomy, with node-level correspondence to functional, microstructural, and diffusion MRI-based measures decreasing along a primary-to-transmodal axis. Relative to primary and paralimbic regions, unimodal and heteromodal regions showed higher receptomic diversification, possibly supporting functional flexibility.
摘要：
化学体系结构，神经递质转运体和受体分子的异质性分布，是人脑结构-功能关系的相关组成部分。这里,我们研究了接收器的组织，区域间化学结构相似性的度量，来自19种不同神经递质转运蛋白和受体的正电子发射断层成像研究。非线性降维揭示了皮质化学结构相似性的三个主要空间梯度-中心时间梯度，枕骨-额叶梯度,和颞枕骨梯度。在皮质下核,化学建筑学相似性区分了功能群落，并描绘了纹状体-丘脑轴。总的来说,皮质受体与功能和结构脑解剖结构共享关键组织特征，具有与功能的节点级对应关系，微观结构,和扩散磁共振成像为基础的措施，沿着一个主要到跨模态轴下降。相对于初级和旁林区，单峰和异峰区域表现出更高的接受体多样性，可能支持功能灵活性。
