{Reference Type}: Journal Article
{Title}: Cerebral chemoarchitecture shares organizational traits with brain structure and function.
{Author}: Hänisch B;Hansen JY;Bernhardt BC;Eickhoff SB;Dukart J;Misic B;Valk SL;
{Journal}: Elife
{Volume}: 12
{Issue}: 0
{Year}: 2023 07 13
{Factor}: 8.713
{DOI}: 10.7554/eLife.83843
{Abstract}: Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and receptor molecules, is a relevant component of structure-function relationships in the human brain. Here, we studied the organization of the receptome, a measure of interareal chemoarchitectural similarity, derived from positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors. Nonlinear dimensionality reduction revealed three main spatial gradients of cortical chemoarchitectural similarity - a centro-temporal gradient, an occipito-frontal gradient, and a temporo-occipital gradient. In subcortical nuclei, chemoarchitectural similarity distinguished functional communities and delineated a striato-thalamic axis. Overall, the cortical receptome shared key organizational traits with functional and structural brain anatomy, with node-level correspondence to functional, microstructural, and diffusion MRI-based measures decreasing along a primary-to-transmodal axis. Relative to primary and paralimbic regions, unimodal and heteromodal regions showed higher receptomic diversification, possibly supporting functional flexibility.