PDF(Pubmed)
Abstract：
UNASSIGNED: East-European data on cancer in patients undergoing hemodialysis (HD) are scarce. This study aimed to assess the pattern of cancer and related mortality in patients with end-stage kidney disease (ESKD) undergoing HD.
UNASSIGNED: Retrospectively analyzing data from 7 HD centers, this study examined 1377 incident HD patients divided into three groups: no-cancers (NoC), cancers that occurred prior to HD initiation (CPI) and de novo cancer developed after HD initiation (DNC). Mortality risk and survival trends within groups were analyzed using Cox regression and Kaplan-Meier methods.
UNASSIGNED: In the cohort, 89.46% of the patients had no cancer (NoC group), 3.63% had cancer before (CPI group), and 6.89% had cancer after HD initiation (DNC group). The mean time from HD initiation to DNC diagnosis was 1 [2.75] years. Older age was associated with a higher risk of developing DNC (p < 0.001). Chronic tubulointerstitial nephritis (CTIN) is more prevalent in cancer patients. The most common cancer sites among DNC patients were the digestive (29.47%) and urinary tracts (18.95%), while those in CPI subjects were hematologic (22%) and digestive (20%). Cancer was an independent predictor of mortality risk (HR = 6.9, 95% [CI]:4.5-10.6, p < 0.001).
UNASSIGNED: East-European ESKD patients undergoing HD have a high incidence of de novo cancers whose primary cancer sites are the digestive and urinary tracts. Almost half of the HD patients with CPI have hematologic and digestive tract cancers. Age and CTIN were associated with cancer risk. Cancer is an independent risk factor for all-cause mortality in patients undergoing hemodialysis (HD).
UNASSIGNED: Retrospectively analyzing data from 7 HD centers, this study examined 1377 incident HD patients divided into three groups: no-cancers (NoC), cancers that occurred prior to HD initiation (CPI) and de novo cancer developed after HD initiation (DNC). Mortality risk and survival trends within groups were analyzed using Cox regression and Kaplan-Meier methods.
UNASSIGNED: In the cohort, 89.46% of the patients had no cancer (NoC group), 3.63% had cancer before (CPI group), and 6.89% had cancer after HD initiation (DNC group). The mean time from HD initiation to DNC diagnosis was 1 [2.75] years. Older age was associated with a higher risk of developing DNC (p < 0.001). Chronic tubulointerstitial nephritis (CTIN) is more prevalent in cancer patients. The most common cancer sites among DNC patients were the digestive (29.47%) and urinary tracts (18.95%), while those in CPI subjects were hematologic (22%) and digestive (20%). Cancer was an independent predictor of mortality risk (HR = 6.9, 95% [CI]:4.5-10.6, p < 0.001).
UNASSIGNED: East-European ESKD patients undergoing HD have a high incidence of de novo cancers whose primary cancer sites are the digestive and urinary tracts. Almost half of the HD patients with CPI have hematologic and digestive tract cancers. Age and CTIN were associated with cancer risk. Cancer is an independent risk factor for all-cause mortality in patients undergoing hemodialysis (HD).
摘要：
■东欧关于血液透析（HD）患者癌症的数据很少。这项研究旨在评估接受HD的终末期肾病（ESKD）患者的癌症模式和相关死亡率。
■回顾性分析来自7个高清中心的数据，这项研究检查了1377例HD患者，分为三组：非癌症（NoC），在HD开始之前发生的癌症（CPI）和在HD开始之后发生的从头癌症（DNC）。使用Cox回归和Kaplan-Meier方法分析组内的死亡率风险和生存趋势。
■在队列中，89.46%的患者没有癌症（NoC组），3.63%以前有癌症（CPI组），6.89%的人在HD开始后(DNC组)有癌症。从HD开始到DNC诊断的平均时间为1[2.75]年。年龄较大与发展DNC的风险较高相关(p<0.001)。慢性肾小管间质性肾炎（CTIN）在癌症患者中更为普遍。DNC患者中最常见的癌症部位是消化道（29.47％）和泌尿道（18.95％），而CPI受试者的血液（22％）和消化系统（20％）。癌症是死亡风险的独立预测因子(HR=6.9,95%[CI]:4.5-10.6,p<0.001)。
接受HD的东欧ESKD患者具有高发病率的新发癌，其原发癌部位是消化道和泌尿道。几乎一半的患有CPI的HD患者患有血液系统和消化道癌症。年龄和CTIN与癌症风险相关。癌症是血液透析（HD）患者全因死亡的独立危险因素。
■回顾性分析来自7个高清中心的数据，这项研究检查了1377例HD患者，分为三组：非癌症（NoC），在HD开始之前发生的癌症（CPI）和在HD开始之后发生的从头癌症（DNC）。使用Cox回归和Kaplan-Meier方法分析组内的死亡率风险和生存趋势。
■在队列中，89.46%的患者没有癌症（NoC组），3.63%以前有癌症（CPI组），6.89%的人在HD开始后(DNC组)有癌症。从HD开始到DNC诊断的平均时间为1[2.75]年。年龄较大与发展DNC的风险较高相关(p<0.001)。慢性肾小管间质性肾炎（CTIN）在癌症患者中更为普遍。DNC患者中最常见的癌症部位是消化道（29.47％）和泌尿道（18.95％），而CPI受试者的血液（22％）和消化系统（20％）。癌症是死亡风险的独立预测因子(HR=6.9,95%[CI]:4.5-10.6,p<0.001)。
接受HD的东欧ESKD患者具有高发病率的新发癌，其原发癌部位是消化道和泌尿道。几乎一半的患有CPI的HD患者患有血液系统和消化道癌症。年龄和CTIN与癌症风险相关。癌症是血液透析（HD）患者全因死亡的独立危险因素。
