PDF(Pubmed)
Abstract：
Middle-aged women belong to a risk group for metabolic dysregulation and menopausal symptoms, mainly due to a dramatic hormonal shift. Supplementation with functional compounds or a single nutrient has been dominantly explored as a nutritional approach for improving aging-related health parameters. However, a meal-based approach might be another strategy for promoting the overall health of the target population. This pilot study aimed to develop a meal-based intervention for middle-aged women and to evaluate its potential health benefits. Considering the nutrient intake status of Korean middle-aged women, diets enriched with four major nutrients (isoflavone, omega-3, fiber, and calcium) were designed and provided to forty-nine women aged 50 to 65 with mild levels of menopausal symptoms for 8 weeks. In the post-intervention phase, they showed reduced body weight and body fat, and improved biochemical metabolic parameters with decreased levels of cholesterol, low-density lipoprotein-cholesterol, ApoB, and fasting insulin. Moreover, bone resorption markers and menopause symptoms were lower in the post-intervention phase. In conclusion, the meal-based intervention might be a prominent strategy for overall health promotion in relatively healthy middle-aged women and further investigation is needed to test its efficacy with a randomized controlled study.
摘要：
中年妇女属于代谢失调和更年期症状的危险人群，主要是由于荷尔蒙的急剧变化。作为改善与衰老相关的健康参数的营养方法，主要探索了补充功能性化合物或单一营养素。然而,基于膳食的方法可能是促进目标人群整体健康的另一种策略。这项初步研究旨在为中年妇女开发基于膳食的干预措施，并评估其潜在的健康益处。考虑到韩国中年女性的营养摄入状况，富含四种主要营养素的饮食(异黄酮，欧米茄-3，纤维，和钙）被设计并提供给49名年龄在50至65岁之间的女性，她们有8周的更年期症状。在干预后阶段，他们显示体重和体内脂肪减少，和改善生化代谢参数，降低胆固醇水平，低密度脂蛋白胆固醇，ApoB,和空腹胰岛素。此外，骨吸收标志物和绝经症状在干预后阶段较低.总之,在相对健康的中年妇女中,以膳食为基础的干预可能是促进整体健康的重要策略,需要进一步的调查,通过随机对照研究来检验其有效性.
