PDF(Pubmed)
Abstract：
UNASSIGNED: A systematic overview of underlying mechanisms in the new disruptive mood dysregulation disorder (DMDD) diagnosis is needed. The Research Domain Criteria (RDoC) represent a system of six domains of human functioning, which aims to structure the understanding of the nature of mental illnesses. By means of the RDoC framework, the objective of this systematic review is to synthesize available data on children and youths <18 years suffering from DMDD as reported in peer reviewed papers.
UNASSIGNED: A literature search guided by PRISMA was conducted using Medline, PsychInfo, and Embase, while the RDoC domains were employed to systematize research findings. Risk of bias in the included studies was examined.
UNASSIGNED: We identified 319 studies. After study selection, we included 29 studies. Twenty-one of these had findings relating to >1 RDoC domain. The risk of bias assessment shows limitations in the research foundation of current knowledge on mechanisms of DMDD.
UNASSIGNED: Reviewing self-report, behavior and neurocircuit findings by means of RDoC domains, we suggest that DMDD youths have a negative interpretation bias in social processes and valence systems. In occurrence of a negative stimuli interpretation, aberrant cognitive processing may arise. However, current knowledge of DMDD is influenced by lack of sample diversity and open science practices.
UNASSIGNED: We found the six RDoC domains useful in structuring current evidence of the underlying mechanisms of DMDD. Important opportunities for future studies in this field of research are suggested. In clinical practice, this comprehensive summary on DMDD mechanisms can be used in psychoeducation and treatment plans.
UNASSIGNED: A literature search guided by PRISMA was conducted using Medline, PsychInfo, and Embase, while the RDoC domains were employed to systematize research findings. Risk of bias in the included studies was examined.
UNASSIGNED: We identified 319 studies. After study selection, we included 29 studies. Twenty-one of these had findings relating to >1 RDoC domain. The risk of bias assessment shows limitations in the research foundation of current knowledge on mechanisms of DMDD.
UNASSIGNED: Reviewing self-report, behavior and neurocircuit findings by means of RDoC domains, we suggest that DMDD youths have a negative interpretation bias in social processes and valence systems. In occurrence of a negative stimuli interpretation, aberrant cognitive processing may arise. However, current knowledge of DMDD is influenced by lack of sample diversity and open science practices.
UNASSIGNED: We found the six RDoC domains useful in structuring current evidence of the underlying mechanisms of DMDD. Important opportunities for future studies in this field of research are suggested. In clinical practice, this comprehensive summary on DMDD mechanisms can be used in psychoeducation and treatment plans.
摘要：
■需要对新的破坏性情绪失调障碍（DMDD）诊断的潜在机制进行系统概述。研究领域标准（RDoC）代表了人类功能的六个领域的系统，旨在构建对精神疾病性质的理解。通过RDoC框架，本系统评价的目的是综合同行评审论文中报道的18岁以下儿童和青少年患有DMDD的现有数据.
■使用Medline进行了由PRISMA指导的文献检索，PsychInfo,和Embase,而RDoC域被用来系统化研究结果。检查了纳入研究中的偏倚风险。
■我们确定了319项研究。经过研究选择，我们纳入了29项研究。其中21个发现与>1个RDoC域有关。偏倚风险评估在当前DMDD机制知识的研究基础上显示出局限性。
■审查自我报告，通过RDoC域的行为和神经回路发现，我们认为DMDD青年在社会过程和效价系统中有负面的解释偏见。在发生负面刺激解释时，可能会出现异常的认知过程。然而,当前对DMDD的知识受到缺乏样本多样性和开放科学实践的影响。
■我们发现六个RDoC域可用于构建DMDD潜在机制的当前证据。建议在该研究领域进行未来研究的重要机会。在临床实践中,这份关于DMDD机制的全面总结可用于心理教育和治疗计划.
■使用Medline进行了由PRISMA指导的文献检索，PsychInfo,和Embase,而RDoC域被用来系统化研究结果。检查了纳入研究中的偏倚风险。
■我们确定了319项研究。经过研究选择，我们纳入了29项研究。其中21个发现与>1个RDoC域有关。偏倚风险评估在当前DMDD机制知识的研究基础上显示出局限性。
■审查自我报告，通过RDoC域的行为和神经回路发现，我们认为DMDD青年在社会过程和效价系统中有负面的解释偏见。在发生负面刺激解释时，可能会出现异常的认知过程。然而,当前对DMDD的知识受到缺乏样本多样性和开放科学实践的影响。
■我们发现六个RDoC域可用于构建DMDD潜在机制的当前证据。建议在该研究领域进行未来研究的重要机会。在临床实践中,这份关于DMDD机制的全面总结可用于心理教育和治疗计划.
