PDF(Pubmed)
Abstract：
Emerging evidence indicates the association between an unhealthy gut and chronic diseases. A healthy gut comprises an intact gut epithelium and balanced gut microbes. Diet is one of the critical factors that modulate gut health by positively or negatively affecting the intestinal barrier and gut microbes. Blueberries are an excellent source of health-promoting bioactive components, and this systematic review is conducted to evaluate the effect of dietary blueberries on gut health. A literature search is conducted on PubMed/MEDLINE, Scopus, Web of Science, and Embase databases to review relevant studies published between 2011 and 2022 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Systematic Review Center for Laboratory Animal Experimentation Risk of Bias (SYRCLE-RoB) tool is used for methodological quality assessments. Sixteen studies included from four countries are reviewed and the results are synthesized narratively. This data analysis indicates that blueberry supplementation improves gut health by improving intestinal morphology, reducing gut permeability, suppressing oxidative stress, ameliorating gut inflammation, and modulating the composition and function of gut microbes. However, there are significant knowledge gaps in this field. These findings indicate that further studies are needed to establish the beneficial effects of blueberries on gut health.
摘要：
新出现的证据表明，不健康的肠道和慢性疾病之间存在关联。健康的肠道包括完整的肠道上皮和平衡的肠道微生物。饮食是通过正面或负面影响肠道屏障和肠道微生物来调节肠道健康的关键因素之一。蓝莓是促进健康的生物活性成分的极好来源，本系统综述旨在评估饮食蓝莓对肠道健康的影响。在PubMed/MEDLINE上进行了文献检索，Scopus,WebofScience,和Embase数据库，根据系统审查和荟萃分析（PRISMA）指南的首选报告项目，审查2011年至2022年之间发布的相关研究。实验室动物实验风险系统审查中心（SYRCLE-RoB）工具用于方法学质量评估。回顾了来自四个国家的16项研究，并对结果进行了叙述综合。该数据分析表明，蓝莓补充剂通过改善肠道形态来改善肠道健康，降低肠道通透性，抑制氧化应激，改善肠道炎症，调节肠道微生物的组成和功能。然而,在这个领域有很大的知识差距。这些发现表明，需要进一步的研究来确定蓝莓对肠道健康的有益作用。
