Abstract：
Neurocysticercosis is a heterogeneous disease, and the patient\'s sex seems to play a role in this heterogeneity. Hosts\' sexual dimorphism in cysticercosis has been largely explored in the murine model of intraperitoneal Taenia crassiceps cysticercosis. In this study, we investigated the sexual dimorphism of inflammatory responses in a rat model of extraparenchymal neurocysticercosis caused by T. crassiceps. T. crassiceps cysticerci were inoculated in the subarachnoid space of Wistar rats (25 females, 22 males). Ninety days later, the rats were euthanized for histologic, immunohistochemistry, and cytokines studies. Ten animals also underwent a 7-T magnetic resonance imaging (MRI). Female rats presented a higher concentration of immune cells in the arachnoid-brain interface, reactive astrogliosis in the periventricular region, in situ pro-inflammatory cytokine (interleukin [IL]-6) and anti-inflammatory cytokine (IL-10), and more intense hydrocephalus on MRI than males. Intracranial hypertension signals were not observed during the observational period. Overall, these results suggest sexual dimorphism in the intracranial inflammatory response that accompanied T. crassiceps extraparenchymal neurocysticercosis.
摘要：
脑囊虫病是一种异质性疾病,患者的性别似乎在这种异质性中起作用。在腹膜内股带虫囊虫病的小鼠模型中，已经对囊虫病中的宿主性二态性进行了大量探索。在这项研究中,我们研究了由T.crusiceps引起的大鼠实质性神经囊虫病模型中炎症反应的性二态性。在Wistar大鼠的蛛网膜下腔中接种了囊尾蚴T。（25只雌性，22名男性）。90天后，对大鼠进行了组织学安乐死，免疫组织化学，和细胞因子研究。10只动物也接受了7-T磁共振成像(MRI)。雌性大鼠在蛛网膜-脑界面呈现较高浓度的免疫细胞，脑室周围区域的反应性星形胶质增生，原位促炎细胞因子（白细胞介素[IL]-6）和抗炎细胞因子（IL-10），MRI上的脑积水比男性更严重。在观察期间未观察到颅内高压信号。总的来说,这些结果提示伴随T.crusiceps脑实质外神经囊虫病的颅内炎症反应中的性二态性。
