Abstract：
Irritable Bowel Syndrome (IBS)-like symptoms are frequent following bariatric surgery. This study aims to evaluate the frequency of IBS symptoms severity before and after bariatric surgery and their association with short-chain fermentable carbohydrates (FODMAPs) consumption.
IBS symptoms severity in a cohort of obese patients was evaluated prospectively before, 6 and 12 months after bariatric surgery by validated questionnaires and tools (Irritable Bowel Syndrome Severity Scoring System (IBS SSS), Bristol Stool Scale (BSS), Quality of Life Short- Form-12 (SF-12), Hospital Anxiety and Depression scale (HAD)). FODMAPs consumption and its association with IBS symptom severity was evaluated by using a food frequency questionnaire focused on high-FODMAPs food consumption.
Fifty-one patients were included (41 female; mean age 41 years (SD: 12)), 84% received a sleeve gastrectomy, and 16% a Roux-en-Y gastric bypass. Symptoms compatible with IBS were observed in 43% of patients before surgery, in 58% of patients at 6 months and 33% at 12 months (NS, p-value=0,197 and 0,414). In a multivariate model, a significant association was found between the IBS SSS score and lactose consumption at 6 months (β = + 58, 1; p = 0.03), and with polyols consumption at 12 months (β = + 112,6; p = 0.01).
Mild to moderate IBS symptoms are frequent in obese patients before bariatric surgery. A significant association between lactose and polyols consumption and IBS SSS score was observed after bariatric surgery, suggesting a potential link between the severity of IBS symptoms and some specific FODMAPs consumption.
IBS symptoms severity in a cohort of obese patients was evaluated prospectively before, 6 and 12 months after bariatric surgery by validated questionnaires and tools (Irritable Bowel Syndrome Severity Scoring System (IBS SSS), Bristol Stool Scale (BSS), Quality of Life Short- Form-12 (SF-12), Hospital Anxiety and Depression scale (HAD)). FODMAPs consumption and its association with IBS symptom severity was evaluated by using a food frequency questionnaire focused on high-FODMAPs food consumption.
Fifty-one patients were included (41 female; mean age 41 years (SD: 12)), 84% received a sleeve gastrectomy, and 16% a Roux-en-Y gastric bypass. Symptoms compatible with IBS were observed in 43% of patients before surgery, in 58% of patients at 6 months and 33% at 12 months (NS, p-value=0,197 and 0,414). In a multivariate model, a significant association was found between the IBS SSS score and lactose consumption at 6 months (β = + 58, 1; p = 0.03), and with polyols consumption at 12 months (β = + 112,6; p = 0.01).
Mild to moderate IBS symptoms are frequent in obese patients before bariatric surgery. A significant association between lactose and polyols consumption and IBS SSS score was observed after bariatric surgery, suggesting a potential link between the severity of IBS symptoms and some specific FODMAPs consumption.
摘要：
减肥手术后，肠易激综合征（IBS）样症状很常见。这项研究旨在评估减肥手术前后IBS症状严重程度的频率及其与短链可发酵碳水化合物（FODMAP）消耗的关联。
■前瞻性评估一组肥胖患者的IBS症状严重程度，减重手术后6个月和12个月，通过经过验证的问卷和工具（肠易激综合征严重程度评分系统（IBSSSS），布里斯托尔凳子秤（BSS），生活质量短形式-12(SF-12)，医院焦虑抑郁量表(HAD))。通过使用针对高FODMAP食物消费的食物频率问卷评估FODMAP消费及其与IBS症状严重程度的关联。
■纳入51名患者（41名女性；平均年龄41岁（SD：12）），84%接受了袖状胃切除术,和16％的Roux-en-Y胃旁路术。43％的患者在手术前观察到与IBS相容的症状，58%的患者在6个月时和33%在12个月时(NS，p值=0,197和0,414)。在多变量模型中，发现IBSSSS评分与6个月时的乳糖摄入量之间存在显着关联（β=58，1；p=0.03），12个月时的多元醇消费量(β=+112,6；p=0.01)。
肥胖患者在减肥手术前经常出现轻度至中度IBS症状。在减肥手术后观察到乳糖和多元醇消耗与IBSSSS评分之间的显着关联，提示IBS症状的严重程度与某些特定FODMAP消耗之间存在潜在联系。
■前瞻性评估一组肥胖患者的IBS症状严重程度，减重手术后6个月和12个月，通过经过验证的问卷和工具（肠易激综合征严重程度评分系统（IBSSSS），布里斯托尔凳子秤（BSS），生活质量短形式-12(SF-12)，医院焦虑抑郁量表(HAD))。通过使用针对高FODMAP食物消费的食物频率问卷评估FODMAP消费及其与IBS症状严重程度的关联。
■纳入51名患者（41名女性；平均年龄41岁（SD：12）），84%接受了袖状胃切除术,和16％的Roux-en-Y胃旁路术。43％的患者在手术前观察到与IBS相容的症状，58%的患者在6个月时和33%在12个月时(NS，p值=0,197和0,414)。在多变量模型中，发现IBSSSS评分与6个月时的乳糖摄入量之间存在显着关联（β=58，1；p=0.03），12个月时的多元醇消费量(β=+112,6；p=0.01)。
肥胖患者在减肥手术前经常出现轻度至中度IBS症状。在减肥手术后观察到乳糖和多元醇消耗与IBSSSS评分之间的显着关联，提示IBS症状的严重程度与某些特定FODMAP消耗之间存在潜在联系。
