Abstract：
Post-stroke depression (PSD), one of the most common complications following stroke, affects approximately one-third of stroke patients and is significantly associated with increased disability and mortality as well as decreased quality of life, which makes it an important public health concern. Treatment of PSD significantly ameliorates depressive symptoms and improves the prognosis of stroke.
The authors discuss the critical aspects of the clinical application of prediction and preventive treatment of PSD. Then, the authors update the biological factors associated with the onset of PSD. Furthermore, they summarize the recent progress in pharmacological preventive treatment in clinical trials and propose potential treatment targets. The authors also discuss the current roadblocks in the preventive treatment of PSD. Finally, the authors put postulate potential directions for future studies so as to discover accurate predictors and provide individualized preventive treatment.
Sorting out high-risk PSD patients using reliable predictors will greatly assist PSD management. Indeed, some predictors not only predict the incidence of PSD but also predict prognosis, which indicates that they might also aid the development of an individualized treatment scheme. Preventive application of antidepressants may also be considered.
The authors discuss the critical aspects of the clinical application of prediction and preventive treatment of PSD. Then, the authors update the biological factors associated with the onset of PSD. Furthermore, they summarize the recent progress in pharmacological preventive treatment in clinical trials and propose potential treatment targets. The authors also discuss the current roadblocks in the preventive treatment of PSD. Finally, the authors put postulate potential directions for future studies so as to discover accurate predictors and provide individualized preventive treatment.
Sorting out high-risk PSD patients using reliable predictors will greatly assist PSD management. Indeed, some predictors not only predict the incidence of PSD but also predict prognosis, which indicates that they might also aid the development of an individualized treatment scheme. Preventive application of antidepressants may also be considered.
摘要：
■卒中后抑郁（PSD），中风后最常见的并发症之一，影响大约三分之一的中风患者，并与残疾和死亡率增加以及生活质量下降显着相关，这使得它成为一个重要的公共卫生问题。PSD的治疗显著改善了抑郁症状并改善了中风的预后。
■作者讨论了PSD的预测和预防性治疗的临床应用的关键方面。然后，作者更新了与PSD发病相关的生物学因素。此外，他们总结了临床试验中药物预防治疗的最新进展，并提出了潜在的治疗目标。作者还讨论了PSD预防性治疗的当前障碍。最后,作者提出了未来研究的潜在方向，以发现准确的预测因素并提供个性化的预防性治疗。
■使用可靠的预测因子对高危PSD患者进行排序将极大地帮助PSD管理。的确,一些预测因子不仅可以预测PSD的发生率，还可以预测预后，这表明它们也可能有助于制定个性化的治疗方案。也可以考虑预防性应用抗抑郁药。
■作者讨论了PSD的预测和预防性治疗的临床应用的关键方面。然后，作者更新了与PSD发病相关的生物学因素。此外，他们总结了临床试验中药物预防治疗的最新进展，并提出了潜在的治疗目标。作者还讨论了PSD预防性治疗的当前障碍。最后,作者提出了未来研究的潜在方向，以发现准确的预测因素并提供个性化的预防性治疗。
■使用可靠的预测因子对高危PSD患者进行排序将极大地帮助PSD管理。的确,一些预测因子不仅可以预测PSD的发生率，还可以预测预后，这表明它们也可能有助于制定个性化的治疗方案。也可以考虑预防性应用抗抑郁药。
