Abstract：
The aim of this prospective cross-sectional cohort study was to test the effect of silicone hydrogel (SH) and rigid gas permeable (RGP) contact lens (CL) wear on corneal sensitivity, applying the new Swiss Liquid Jet Aesthesiometer for Corneal Sensitivity (SLACS) and the Cochet-Bonnet (CB) aesthesiometer, based on subject feedback (psychophysical method).
Participants were recruited for three equally large groups: Group A (SH CL), Group B (RGP CL) and Group C (non-CL wearers). Inclusion criteria were healthy eyes and OSDI ≤ 13. Corneal sensory thresholds were determined twice during two visits, with aid of SLACS and CB.
96 participants completed the study (n = 33 in groups A and C, n = 30 in group B); average age in group A: 27.42 ± 6.83 years, group B: 36.90 ± 9.68 years and group C: 26.06 ± 6.19 years. No statistically significant difference in corneal sensitivity was observed between the three groups for either method (p = 0.302 for SLACS, p = 0.266 for CB; Kruskal-Wallis rank sum test). Higher CSTs were obtained for males than for females in both CL groups with SLACS, and with CB only in the RGP CL group (p = 0.041 in Group A, p = 0.006 in Group B with SLACS; p = 0.041 in Group B with CB; bootstrap analysis with age correction and gender balancing). No correlation was observed between CL comfort and corneal sensitivity for neither method applied (for SLACS r = 0.097 and p = 0.51, for CB r = 0.17 and p = 0.15; robust linear mixed model).
No difference in corneal sensitivity with CL compared to non-CL wear was noted in this study. However, lower levels of corneal sensitivity were observed in the male CL groups, warranting further investigation.
Participants were recruited for three equally large groups: Group A (SH CL), Group B (RGP CL) and Group C (non-CL wearers). Inclusion criteria were healthy eyes and OSDI ≤ 13. Corneal sensory thresholds were determined twice during two visits, with aid of SLACS and CB.
96 participants completed the study (n = 33 in groups A and C, n = 30 in group B); average age in group A: 27.42 ± 6.83 years, group B: 36.90 ± 9.68 years and group C: 26.06 ± 6.19 years. No statistically significant difference in corneal sensitivity was observed between the three groups for either method (p = 0.302 for SLACS, p = 0.266 for CB; Kruskal-Wallis rank sum test). Higher CSTs were obtained for males than for females in both CL groups with SLACS, and with CB only in the RGP CL group (p = 0.041 in Group A, p = 0.006 in Group B with SLACS; p = 0.041 in Group B with CB; bootstrap analysis with age correction and gender balancing). No correlation was observed between CL comfort and corneal sensitivity for neither method applied (for SLACS r = 0.097 and p = 0.51, for CB r = 0.17 and p = 0.15; robust linear mixed model).
No difference in corneal sensitivity with CL compared to non-CL wear was noted in this study. However, lower levels of corneal sensitivity were observed in the male CL groups, warranting further investigation.
摘要：
目的：这项前瞻性横断面队列研究的目的是测试硅水凝胶（SH）和刚性透气（RGP）隐形眼镜（CL）佩戴对角膜敏感性的影响，应用新的瑞士液体喷射麻醉仪角膜灵敏度（SLACS）和Cochet-Bonnet（CB）麻醉仪，基于受试者反馈(心理物理学方法)。
方法：参与者被招募为三个同样大的组：A组（SHCL），B组(RGPCL)和C组(非CL穿戴者)。纳入标准为健康眼睛和OSDI≤13。在两次访视期间两次确定角膜感觉阈值，借助SLACS和CB。
结果：96名参与者完成了研究（A组和C组n=33，B组n=30）；A组平均年龄：27.42±6.83岁，B组:36.90±9.68岁,C组:26.06±6.19岁。对于任一方法，三组之间的角膜敏感性均未观察到统计学上的显着差异（对于SLACS，p=0.302，CB的p=0.266；Kruskal-Wallis秩和检验)。在SLACS的两个CL组中，男性的CST均高于女性，仅在RGPCL组中使用CB（A组中p=0.041，使用SLACS的B组p=0.006；使用CB的B组p=0.041；具有年龄校正和性别平衡的引导分析）。对于两种方法，CL舒适度和角膜敏感性之间均未观察到相关性（对于SLACSr=0.097和p=0.51，对于CBr=0.17和p=0.15；稳健的线性混合模型）。
结论：在这项研究中，与非CL佩戴相比，CL佩戴的角膜敏感性没有差异。然而,在男性CL组中观察到较低水平的角膜敏感性，保证进一步调查。
方法：参与者被招募为三个同样大的组：A组（SHCL），B组(RGPCL)和C组(非CL穿戴者)。纳入标准为健康眼睛和OSDI≤13。在两次访视期间两次确定角膜感觉阈值，借助SLACS和CB。
结果：96名参与者完成了研究（A组和C组n=33，B组n=30）；A组平均年龄：27.42±6.83岁，B组:36.90±9.68岁,C组:26.06±6.19岁。对于任一方法，三组之间的角膜敏感性均未观察到统计学上的显着差异（对于SLACS，p=0.302，CB的p=0.266；Kruskal-Wallis秩和检验)。在SLACS的两个CL组中，男性的CST均高于女性，仅在RGPCL组中使用CB（A组中p=0.041，使用SLACS的B组p=0.006；使用CB的B组p=0.041；具有年龄校正和性别平衡的引导分析）。对于两种方法，CL舒适度和角膜敏感性之间均未观察到相关性（对于SLACSr=0.097和p=0.51，对于CBr=0.17和p=0.15；稳健的线性混合模型）。
结论：在这项研究中，与非CL佩戴相比，CL佩戴的角膜敏感性没有差异。然而,在男性CL组中观察到较低水平的角膜敏感性，保证进一步调查。
