Abstract：
Lower urinary tract obstruction (LUTO) is a rare birth defect with a prevalence between 1 in 5,000 and 1 in 25,000 pregnancies. LUTO is one of the most common causes of congenital abnormalities of the renal tract. Several genetic conditions have been associated with LUTO. Most common causes of LUTO are posterior urethral valves and urethral atresia. Despite available prenatal and postnatal treatments, LUTO is a significant cause of morbidity and mortality in newborns causing significant end stage renal disease and pulmonary hypoplasia.
摘要：
下尿路梗阻（LUTO）是一种罕见的出生缺陷，患病率在5,000到25,000的1之间。LUTO是先天性肾道异常的最常见原因之一。几种遗传条件与LUTO有关。LUTO最常见的原因是后尿道瓣膜和尿道闭锁。尽管有产前和产后治疗，LUTO是导致严重终末期肾病和肺发育不全的新生儿发病和死亡的重要原因。
