PDF(Pubmed)
Abstract：
The interplay between pathogen and host determines the immune response during viral infection. The Nod‑like receptor (NLR) protein 3 inflammasome is a multiprotein complex that induces the activation of inflammatory caspases and the release of IL‑1β, which play an important role in the innate immune responses. In the present review, the mechanisms of the NLR family pyrin domain containing 3 inflammasome activation and its dysregulation in viral infection were addressed.
摘要：
病原体和宿主之间的相互作用决定了病毒感染期间的免疫应答。Nod样受体（NLR）蛋白3炎性体是一种多蛋白复合物，可诱导炎性半胱天冬酶的激活和IL-1β的释放，在先天免疫反应中起着重要作用。在本次审查中，研究了NLR家族pyrin域包含3个炎性体的激活及其在病毒感染中的失调机制。
