PDF(Pubmed)
Abstract：
UNASSIGNED: The objective of this review is to systematically analyze the available literature on the effects of titanium oxide (TiO₂) coating on the antimicrobial properties, surface characteristics, and cytotoxicity of orthodontic brackets.
UNASSIGNED: In-vitro studies reporting on the effects of Titanium oxide (TiO₂) coatings on antimicrobial properties, surface roughness, cytotoxic activity and bacterial adhesion of orthodontic brackets were included in the review. Electronic databases such as PubMed, SCOPUS, Web of Science and Google Scholar, were searched till September 2022. Risk of Bias was analyzed by using RoBDEMAT tool. Meta-analysis using Random Effects Model was performed for assessing the antimicrobial activity against S. mutans, C. albicans and L. Acidophilus.
UNASSIGNED: A total of 11 studies were included the RoB analysis revealed sufficient reporting across all the domains and inconsistent reporting in only two of the domains. On qualitative analysis, a significant antimicrobial effect of TiO2 coating on orthodontic brackets against Streptococcus mutans, Candida albicans and Lactobacillus acidophilus was reported. The meta analysis revealed a significant overall antimicrobial effect with a high heterogeneity. (SMD: 3.5; p < 0.00001; i2 - 99.2%).
UNASSIGNED: An overall significant antimicrobial effect of TiO₂ coated brackets against S. mutans, L. Acidophilus, C. Albicans was noted but with a high heterogeneity. The subgroup analysis revealed a significant antimicrobial effect on C albicans with a low heterogeneity but it was limited by a publication bias. The included studies reported reduced surface roughness, minimal bacterial adhesion and less cytotoxic activity with TiO₂ coated brackets than uncoated brackets.
UNASSIGNED: In-vitro studies reporting on the effects of Titanium oxide (TiO₂) coatings on antimicrobial properties, surface roughness, cytotoxic activity and bacterial adhesion of orthodontic brackets were included in the review. Electronic databases such as PubMed, SCOPUS, Web of Science and Google Scholar, were searched till September 2022. Risk of Bias was analyzed by using RoBDEMAT tool. Meta-analysis using Random Effects Model was performed for assessing the antimicrobial activity against S. mutans, C. albicans and L. Acidophilus.
UNASSIGNED: A total of 11 studies were included the RoB analysis revealed sufficient reporting across all the domains and inconsistent reporting in only two of the domains. On qualitative analysis, a significant antimicrobial effect of TiO2 coating on orthodontic brackets against Streptococcus mutans, Candida albicans and Lactobacillus acidophilus was reported. The meta analysis revealed a significant overall antimicrobial effect with a high heterogeneity. (SMD: 3.5; p < 0.00001; i2 - 99.2%).
UNASSIGNED: An overall significant antimicrobial effect of TiO₂ coated brackets against S. mutans, L. Acidophilus, C. Albicans was noted but with a high heterogeneity. The subgroup analysis revealed a significant antimicrobial effect on C albicans with a low heterogeneity but it was limited by a publication bias. The included studies reported reduced surface roughness, minimal bacterial adhesion and less cytotoxic activity with TiO₂ coated brackets than uncoated brackets.
摘要：
■这篇综述的目的是系统分析有关氧化钛（TiO2）涂层对抗菌性能的影响的现有文献，表面特性，正畸托槽的细胞毒性。
■体外研究报告了氧化钛（TiO2）涂层对抗菌性能的影响，表面粗糙度,该综述包括正畸托槽的细胞毒性活性和细菌粘附。电子数据库，如PubMed，Scopus,WebofScience和谷歌学者，被搜索到2022年9月。使用RoBDEMAT工具分析偏差风险。使用随机效应模型进行荟萃分析，以评估抗变形链球菌的抗菌活性，白色念珠菌和嗜酸乳杆菌。
■总共包括11项研究，RoB分析显示所有领域的报告都足够，只有两个领域的报告不一致。在定性分析上，TiO2涂层对正畸托槽对变形链球菌的显着抗菌作用，报道了白色念珠菌和嗜酸乳杆菌。荟萃分析显示，具有高度异质性的显着总体抗菌作用。(SMD:3.5;p<0.00001;i2-99.2%)。
■TiO2涂层托槽对变形链球菌的总体抗菌效果显着，L.嗜酸,注意到白色念珠菌，但异质性很高。亚组分析显示，具有低异质性的白色念珠菌具有显着的抗菌作用，但受到发表偏倚的限制。纳入的研究报告表面粗糙度降低，与未涂覆支架相比，涂覆TiO2支架的细菌粘附最小，细胞毒性较小。
■体外研究报告了氧化钛（TiO2）涂层对抗菌性能的影响，表面粗糙度,该综述包括正畸托槽的细胞毒性活性和细菌粘附。电子数据库，如PubMed，Scopus,WebofScience和谷歌学者，被搜索到2022年9月。使用RoBDEMAT工具分析偏差风险。使用随机效应模型进行荟萃分析，以评估抗变形链球菌的抗菌活性，白色念珠菌和嗜酸乳杆菌。
■总共包括11项研究，RoB分析显示所有领域的报告都足够，只有两个领域的报告不一致。在定性分析上，TiO2涂层对正畸托槽对变形链球菌的显着抗菌作用，报道了白色念珠菌和嗜酸乳杆菌。荟萃分析显示，具有高度异质性的显着总体抗菌作用。(SMD:3.5;p<0.00001;i2-99.2%)。
■TiO2涂层托槽对变形链球菌的总体抗菌效果显着，L.嗜酸,注意到白色念珠菌，但异质性很高。亚组分析显示，具有低异质性的白色念珠菌具有显着的抗菌作用，但受到发表偏倚的限制。纳入的研究报告表面粗糙度降低，与未涂覆支架相比，涂覆TiO2支架的细菌粘附最小，细胞毒性较小。
