Abstract：
We present a challenging case that illustrates how the clinical manifestations in children with CFTR mutations of uncertain significance may change over time. This case highlights the evolution of confirming a diagnosis of CF and emphasises the importance of regular review and monitoring of this patient cohort.
摘要：
我们提出了一个具有挑战性的案例，说明了具有不确定意义的CFTR突变的儿童的临床表现如何随时间变化。该病例强调了确认CF诊断的进展，并强调了定期审查和监测该患者队列的重要性。
