Abstract：
Cerium oxide nanoparticles have now significant presence in biomedical fields due to their wide applications; however, challenges regarding their safety and biocompatibility persist. Polysaccharides based biopolymers have inherent hydroxyl and carboxyl groups, enabling them to govern the surface functionalization of cerium oxide nanoparticles, hence their chemical and physical characteristics. Because of this, polysaccharides such as dextran, alginate, pullulan, chitosan, polylactic acid, starch, and pectin are practical substitutes for the conventional coatings used to synthesize cerium oxide nanoparticles. This review discusses the effect of biopolymer coatings on the properties of cerium oxide nanoparticles, such as size, stability, aggregation, and biocompatibility. Additionally, it also summarises various biomedical applications of polysaccharides coated cerium oxide nanoparticles, such as in bone tissue regeneration, liver inflammation, wound healing, and antibacterial and anticancer activities. Biocompatible cerium oxide nanoparticles will surely improve their applications in the biomedical field.
摘要：
由于其广泛应用，氧化铈纳米颗粒现在在生物医学领域具有重要的存在;然而，关于其安全性和生物相容性的挑战仍然存在。基于多糖的生物聚合物具有固有的羟基和羧基，使它们能够控制氧化铈纳米颗粒的表面功能化，因此它们的化学和物理特性。正因为如此,多糖如葡聚糖，海藻酸盐,普鲁兰,壳聚糖,聚乳酸,淀粉，果胶,和葡萄糖是用于合成氧化铈纳米颗粒的常规涂层的实际替代品。这篇综述讨论了生物聚合物涂层对氧化铈纳米颗粒性能的影响，比如尺寸，稳定性,聚合，和生物相容性。此外,它还总结了多糖包覆的氧化铈纳米颗粒的各种生物医学应用，例如在骨组织再生中，肝脏炎症,伤口愈合，和抗菌和抗癌活性。生物相容性氧化铈纳米颗粒必将提高其在生物医学领域的应用。
