PDF(Pubmed)
Abstract：
Postoperative neurocognitive disorders (PNDs) are characterised by gradual cognitive decline or change occurring after anaesthesia and surgery, and they are common in patients undergoing orthopaedic surgery. The onset of PNDs has been associated with dementia or other types of neurocognitive disorders in later life. Moreover, cerebrospinal fluid (CSF) biomarkers of neuroinflammation, including amyloid beta-40 peptide, amyloid beta-42 peptide, total tau protein, phosphorylated tau protein and neurofilament light chain, have been reported to be crucial in several high-quality clinical studies on PNDs. However, the role of these biomarkers in the onset of PNDs remains controversial. Therefore, this study aims to determine the association between CSF biomarkers of neuroinflammation and the onset of PNDs in patients undergoing orthopaedic surgery, which will provide novel insights for investigating PNDs and other types of dementia.
This systematic review and meta-analysis will be conducted in accordance with the Preferred Reporting Items for Systematic Reviewd and Meta-Analyses 2020 statement. Moreover, we will search MEDLINE (via OVID), EMBASE and the Cochrane Library without any language and date restrictions. Observational studies will be included. Two reviewers will independently perform the entire procedure, and disagreements will be settled by discussion between them and consultation with a third reviewer. Standardised electronic forms will be generated to extract data. The risk of bias in the individual studies will be evaluated using the Newcastle-Ottawa scale. All statistical analyses will be performed using the RevMan software or the Stata software.
This study will include peer-reviewed published articles; thus, no ethical issues will be involved. Further, the final manuscript will be published in a peer-reviewed journal.
CRD42022380180.
This systematic review and meta-analysis will be conducted in accordance with the Preferred Reporting Items for Systematic Reviewd and Meta-Analyses 2020 statement. Moreover, we will search MEDLINE (via OVID), EMBASE and the Cochrane Library without any language and date restrictions. Observational studies will be included. Two reviewers will independently perform the entire procedure, and disagreements will be settled by discussion between them and consultation with a third reviewer. Standardised electronic forms will be generated to extract data. The risk of bias in the individual studies will be evaluated using the Newcastle-Ottawa scale. All statistical analyses will be performed using the RevMan software or the Stata software.
This study will include peer-reviewed published articles; thus, no ethical issues will be involved. Further, the final manuscript will be published in a peer-reviewed journal.
CRD42022380180.
摘要：
背景：术后神经认知障碍（PND）的特征是在麻醉和手术后逐渐发生认知功能下降或改变，它们在接受骨科手术的患者中很常见。PND的发作与以后生活中的痴呆或其他类型的神经认知障碍有关。此外，脑脊液（CSF）神经炎症的生物标志物，包括淀粉样蛋白β-40肽,淀粉样β-42肽，总tau蛋白，磷酸化tau蛋白和神经丝轻链，据报道，在几项高质量的PND临床研究中至关重要。然而,这些生物标志物在PNDs发病中的作用仍存在争议.因此,这项研究旨在确定神经炎症的CSF生物标志物与骨科手术患者PNDs发病之间的关联，这将为研究PND和其他类型的痴呆症提供新的见解。
方法：本系统综述和荟萃分析将根据2020年系统综述和荟萃分析的首选报告项目声明进行。此外，我们将搜索MEDLINE（通过OVID），EMBASE和Cochrane图书馆没有任何语言和日期限制。将包括观察性研究。两名评审员将独立执行整个过程，分歧将通过他们之间的讨论和与第三位审稿人协商来解决。将生成标准化的电子表格来提取数据。将使用纽卡斯尔-渥太华量表评估个体研究中的偏倚风险。所有统计分析将使用RevMan软件或Stata软件进行。
背景：这项研究将包括同行评审的已发表的文章；因此，不会涉及任何道德问题。Further,最终稿件将发表在同行评审的期刊上.
■CRD42022380180。
方法：本系统综述和荟萃分析将根据2020年系统综述和荟萃分析的首选报告项目声明进行。此外，我们将搜索MEDLINE（通过OVID），EMBASE和Cochrane图书馆没有任何语言和日期限制。将包括观察性研究。两名评审员将独立执行整个过程，分歧将通过他们之间的讨论和与第三位审稿人协商来解决。将生成标准化的电子表格来提取数据。将使用纽卡斯尔-渥太华量表评估个体研究中的偏倚风险。所有统计分析将使用RevMan软件或Stata软件进行。
背景：这项研究将包括同行评审的已发表的文章；因此，不会涉及任何道德问题。Further,最终稿件将发表在同行评审的期刊上.
■CRD42022380180。
