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Abstract：
The associations of plasma factor VIII (FVIII) and factor IX (FIX) levels with risk of venous thromboembolism (VTE) are not well defined. We performed a systematic review and meta-analysis of these associations.
Random effects inverse-variance weighted meta-analysis was used to estimate pooled odds ratios for comparisons across equal quartiles of the distributions and 90 % thresholds (higher versus lower), and for testing linear trends.
Among 15 studies (5327 cases) the pooled odds ratio of VTE for the fourth versus first quarter was 3.92 (95 % confidence interval 1.61, 5.29) for FVIII level; and among 7 studies (3498 cases) 1.57 (1.32, 1.87) for FIX level. Comparing factor levels above, versus below, the 90th percentile, the estimated pooled odds ratios were 3.00 (2.10, 4.30) for FVIII; 1.77 (1.22, 2.56) for FIX; and 4.56 (2.73, 7.63) for both FVIII and FIX considered jointly.
We confirm increases in risk of VTE across population distributions of FVIII and FIX levels. Levels above the 90th percentile have almost twice the risk for FIX level compared to levels below; three-fold risk for FVIII level; and almost five-fold risk for both FVIII and FIX levels elevated.
Random effects inverse-variance weighted meta-analysis was used to estimate pooled odds ratios for comparisons across equal quartiles of the distributions and 90 % thresholds (higher versus lower), and for testing linear trends.
Among 15 studies (5327 cases) the pooled odds ratio of VTE for the fourth versus first quarter was 3.92 (95 % confidence interval 1.61, 5.29) for FVIII level; and among 7 studies (3498 cases) 1.57 (1.32, 1.87) for FIX level. Comparing factor levels above, versus below, the 90th percentile, the estimated pooled odds ratios were 3.00 (2.10, 4.30) for FVIII; 1.77 (1.22, 2.56) for FIX; and 4.56 (2.73, 7.63) for both FVIII and FIX considered jointly.
We confirm increases in risk of VTE across population distributions of FVIII and FIX levels. Levels above the 90th percentile have almost twice the risk for FIX level compared to levels below; three-fold risk for FVIII level; and almost five-fold risk for both FVIII and FIX levels elevated.
摘要：
背景：血浆因子VIII（FVIII）和因子IX（FIX）水平与静脉血栓栓塞（VTE）风险的关系尚不明确。我们对这些关联进行了系统评价和荟萃分析。
方法：使用随机效应逆方差加权荟萃分析来估计在分布的相等四分位数和90％阈值（较高与较低）之间进行比较的合并赔率比。并用于测试线性趋势。
结果：在15项研究（5327例）中，第四季度与第一季度的VTE合并比值比为FVIII水平为3.92（95％置信区间1.61，5.29）；在7项研究（3498例）中，FIX水平为1.57（1.32，1.87）。比较上述因素水平，与下面相比，第90百分位数，FVIII的估计合并比值比为3.00(2.10,4.30);FIX为1.77(1.22,2.56);FVIII和FIX的估计比值比为4.56(2.73,7.63).
结论：我们确认在FVIII和FIX水平的人群分布中，VTE的风险增加。高于第90百分位数的水平与以下水平相比，FIX水平的风险几乎是两倍；FVIII水平的风险是三倍；FVIII和FIX水平升高的风险几乎是五倍。
方法：使用随机效应逆方差加权荟萃分析来估计在分布的相等四分位数和90％阈值（较高与较低）之间进行比较的合并赔率比。并用于测试线性趋势。
结果：在15项研究（5327例）中，第四季度与第一季度的VTE合并比值比为FVIII水平为3.92（95％置信区间1.61，5.29）；在7项研究（3498例）中，FIX水平为1.57（1.32，1.87）。比较上述因素水平，与下面相比，第90百分位数，FVIII的估计合并比值比为3.00(2.10,4.30);FIX为1.77(1.22,2.56);FVIII和FIX的估计比值比为4.56(2.73,7.63).
结论：我们确认在FVIII和FIX水平的人群分布中，VTE的风险增加。高于第90百分位数的水平与以下水平相比，FIX水平的风险几乎是两倍；FVIII水平的风险是三倍；FVIII和FIX水平升高的风险几乎是五倍。
