关键词: Biochemical predictors Children Enterocolitis Ibadan

来  源:   DOI:   PDF(Pubmed)

Abstract:
UNASSIGNED: A large proportion of patients with preoperative enterocolitis still have enterocolitis persisting even after surgery while others resolve thereafter. Some researchers have studied Calprotectin, C-reactive protein (CRP), Blood and Plasma viscosity as markers of inflammation, hence, the choice of their use. The aim of the study is to determine the sensitivity and reliability of Calprotectin, C-reactive protein (CRP), Blood and Plasma viscosity as biochemical predictors of enterocolitis in children with colorectal anomaly post-surgery at University College Hospital Ibadan.
UNASSIGNED: This is an observational analytic study of 32 patients with either Hirschsprung\'s disease or Anorectal malformation carried out over a year period. The demographic data of the patients, clinical condition and the preoperative and postoperative readings of the biochemical analytes were recorded in a chart. Statistical analysis were carried out using SPSS version 23 and test for statistical association done.
UNASSIGNED: The incidence of Hirschsprung associated enterocolitis is 12.5% and for Ano rectal malformation 6.3 %. Gender difference was not statistically significant even with the observed clinical difference. Plasma viscosity and blood viscosity correlate positively with each order. C-reactive Protein and Calprotectin did not predict enterocolitis in this study and the Sensitivity of blood viscosity at T1 and T2 is as low as 66% with a Positive Predictive Value of 25 %.
UNASSIGNED: The incidence of Enterocolitis associated with Hirschsprung\'s disease and Anorectal malformation is 19 %. Calprotectin and C-reactive protein did not predict enterocolitis in this patients. The outcome of care was satisfactory in over 90 % of the patients.
摘要:
很大比例的术前小肠结肠炎患者即使在手术后仍有小肠结肠炎持续存在,而其他人则在手术后消退。一些研究人员研究了钙卫蛋白,C反应蛋白(CRP),血液和血浆粘度作为炎症的标志物,因此,他们使用的选择。该研究的目的是确定钙卫蛋白的敏感性和可靠性,C反应蛋白(CRP),血液和血浆粘度可作为伊巴丹大学学院医院结直肠异常术后儿童小肠结肠炎的生化预测因子。
这是一项为期一年的观察性分析研究,对32名患有先天性巨结肠病或肛门直肠畸形的患者进行。患者的人口统计数据,临床状况以及术前和术后生化分析物的读数记录在图表中.使用SPSS版本23进行统计分析,并进行统计关联检验。
先天性巨结肠相关性小肠结肠炎的发生率为12.5%,肛门直肠畸形的发生率为6.3%。即使观察到临床差异,性别差异也没有统计学意义。血浆粘度和血液粘度与每个顺序呈正相关。在这项研究中,C反应蛋白和钙卫蛋白不能预测小肠结肠炎,T1和T2时血液粘度的敏感性低至66%,阳性预测值为25%。
与先天性巨结肠病和肛门直肠畸形相关的小肠结肠炎的发生率为19%。钙卫蛋白和C反应蛋白不能预测这些患者的小肠结肠炎。超过90%的患者的护理结果令人满意。
公众号