PDF(Pubmed)
Abstract：
UNASSIGNED: Type 2 diabetic retinopathy is a long-term chronic inflammatory disease. The aim of this study was to investigate the relationship between fibrinogen to albumin ratio (FAR) and retinopathy in type 2 diabetic patients.
UNASSIGNED: This was a retrospective study that included 500 patients with type 2 diabetes mellitus (T2DM), and were divided into non-diabetic retinopathy group (NDR, n=297) and diabetic retinopathy group (DR, n=203) according to fundus examination findings, and the DR group was further divided into non-proliferative retinopathy group (NPDR, n=182) and proliferative retinopathy group (PDR, n=21). Baseline data of patients were collected, and the fibrinogen to albumin ratio (FAR) and neutrophil to lymphocyte ratio (NLR) were calculated to analyze the correlation between FAR and NLR and type 2 diabetic retinopathy.
UNASSIGNED: The FAR and NLR were significantly higher in the DR group compared with the NDR group (both P < 0.001). Spearman correlation analysis showed that FAR was positively correlated with NLR and DR (P < 0.05). As the FAR quartile increased, the prevalence of DR increased (14.8%, 16.7%, 25.1%, and 43.30%, respectively; P < 0.05). Multifactorial logistic regression analysis showed that FAR, diabetic course, systolic blood pressure (SBP) and diabetic peripheral neuropathy (DPN) were risk factors for the development of DR in patients with T2DM. The area under the ROC curve for FAR to predict DR progression was 0.708, with an optimal critical value of 7.04, and the area under the ROC curve for diabetes duration and SBP to predict DR was 0.705 and 0.588, respectively.
UNASSIGNED: Our findings show for the first time that FAR is an independent risk factor for assessing DR in patients with type 2 diabetes.
UNASSIGNED: This was a retrospective study that included 500 patients with type 2 diabetes mellitus (T2DM), and were divided into non-diabetic retinopathy group (NDR, n=297) and diabetic retinopathy group (DR, n=203) according to fundus examination findings, and the DR group was further divided into non-proliferative retinopathy group (NPDR, n=182) and proliferative retinopathy group (PDR, n=21). Baseline data of patients were collected, and the fibrinogen to albumin ratio (FAR) and neutrophil to lymphocyte ratio (NLR) were calculated to analyze the correlation between FAR and NLR and type 2 diabetic retinopathy.
UNASSIGNED: The FAR and NLR were significantly higher in the DR group compared with the NDR group (both P < 0.001). Spearman correlation analysis showed that FAR was positively correlated with NLR and DR (P < 0.05). As the FAR quartile increased, the prevalence of DR increased (14.8%, 16.7%, 25.1%, and 43.30%, respectively; P < 0.05). Multifactorial logistic regression analysis showed that FAR, diabetic course, systolic blood pressure (SBP) and diabetic peripheral neuropathy (DPN) were risk factors for the development of DR in patients with T2DM. The area under the ROC curve for FAR to predict DR progression was 0.708, with an optimal critical value of 7.04, and the area under the ROC curve for diabetes duration and SBP to predict DR was 0.705 and 0.588, respectively.
UNASSIGNED: Our findings show for the first time that FAR is an independent risk factor for assessing DR in patients with type 2 diabetes.
摘要：
■2型糖尿病性视网膜病是一种长期的慢性炎症性疾病。本研究旨在探讨2型糖尿病患者纤维蛋白原与白蛋白比值(FAR)与视网膜病变的关系。
■这是一项回顾性研究，包括500名2型糖尿病（T2DM）患者，并分为非糖尿病性视网膜病变组(NDR，n=297）和糖尿病视网膜病变组（DR，n=203)根据眼底检查结果，DR组进一步分为非增生性视网膜病变组（NPDR，n=182）和增生性视网膜病变组（PDR，n=21)。收集患者的基线数据,计算纤维蛋白原与白蛋白比值（FAR）和中性粒细胞与淋巴细胞比值（NLR），分析FAR和NLR与2型糖尿病视网膜病变的相关性。
■DR组的FAR和NLR明显高于NDR组（均P<0.001）。Spearman相关分析显示,FAR与NLR、DR呈正相关(P<0.05)。随着远四分位数的增加，DR的患病率增加（14.8%，16.7%,25.1%,和43.30%，分别；P<0.05）。多因素Logistic回归分析表明，糖尿病病程，收缩压（SBP）和糖尿病周围神经病变（DPN）是T2DM患者发生DR的危险因素。FAR预测DR进展的ROC曲线下面积为0.708，最佳临界值为7.04，糖尿病病程和SBP预测DR的ROC曲线下面积分别为0.705和0.588。
■我们的发现首次表明FAR是评估2型糖尿病患者DR的独立危险因素。
■这是一项回顾性研究，包括500名2型糖尿病（T2DM）患者，并分为非糖尿病性视网膜病变组(NDR，n=297）和糖尿病视网膜病变组（DR，n=203)根据眼底检查结果，DR组进一步分为非增生性视网膜病变组（NPDR，n=182）和增生性视网膜病变组（PDR，n=21)。收集患者的基线数据,计算纤维蛋白原与白蛋白比值（FAR）和中性粒细胞与淋巴细胞比值（NLR），分析FAR和NLR与2型糖尿病视网膜病变的相关性。
■DR组的FAR和NLR明显高于NDR组（均P<0.001）。Spearman相关分析显示,FAR与NLR、DR呈正相关(P<0.05)。随着远四分位数的增加，DR的患病率增加（14.8%，16.7%,25.1%,和43.30%，分别；P<0.05）。多因素Logistic回归分析表明，糖尿病病程，收缩压（SBP）和糖尿病周围神经病变（DPN）是T2DM患者发生DR的危险因素。FAR预测DR进展的ROC曲线下面积为0.708，最佳临界值为7.04，糖尿病病程和SBP预测DR的ROC曲线下面积分别为0.705和0.588。
■我们的发现首次表明FAR是评估2型糖尿病患者DR的独立危险因素。
