Abstract：
Psoriasis is a chronic immune-mediated inflammatory skin disease that involves a complex interplay between infiltrated immune cells and keratinocytes. Great progress has been made in the research on the molecular mechanism of coding and non-coding genes, which has helped in clinical treatment. However, our understanding of this complex disease is far from clear. MicroRNAs (miRNAs) are small non-coding RNA molecules that are involved in post-transcriptional regulation, characterised by their role in mediating gene silencing. Recent studies on miRNAs have revealed their important role in the pathogenesis of psoriasis. We reviewed the current advances in the study of miRNAs in psoriasis; the existing research has found that dysregulated miRNAs in psoriasis notably affect keratinocyte proliferation and/or differentiation processes, as well as inflammation progress. In addition, miRNAs also influence the function of immune cells in psoriasis, including CD4+ T cells, dendritic cells, Langerhans cells and so on. In addition, we discuss possible miRNA-based therapy for psoriasis, such as the topical delivery of exogenous miRNAs, miRNA antagonists and miRNA mimics. Our review highlights the potential role of miRNAs in the pathogenesis of psoriasis, and we expect more research progress with miRNAs in the future, which will help us understand this complex skin disease more accurately.
摘要：
牛皮癣是一种慢性免疫介导的炎症性皮肤病，涉及浸润的免疫细胞和角质形成细胞之间的复杂相互作用。编码和非编码基因的分子机制研究取得了很大进展,这有助于临床治疗。然而,我们对这种复杂疾病的理解还很不清楚。microRNAs(miRNAs)是参与转录后调控的非编码小RNA分子,以它们在介导基因沉默中的作用为特征。最近对miRNA的研究揭示了它们在银屑病发病机制中的重要作用。我们回顾了银屑病中miRNA的研究进展；现有研究发现银屑病中miRNA的失调显著影响角质形成细胞的增殖和/或分化过程。以及炎症的进展。此外,miRNA还影响银屑病免疫细胞的功能，包括CD4+T细胞,树突状细胞,朗格汉斯细胞等等。此外,我们讨论了可能的基于miRNA的银屑病治疗，例如外源miRNA的局部递送，miRNA拮抗剂和miRNA模拟物。我们的综述强调了miRNA在银屑病发病机制中的潜在作用。我们预计未来会有更多关于miRNA的研究进展，这将有助于我们更准确地理解这种复杂的皮肤病。
