Synthesis of aliphatic nitriles from cyclobutanone oxime mediated by sulfuryl fluoride (SO2F2).

磺酰氟 (SO2F2) 介导的环丁酮肟合成脂肪族腈.

• 影响指数: 2.544
• 发表时间: 2023
• 来源期刊: Beilstein J Org Chem
• DOI: 10.3762/bjoc.19.68
• PMID: 37377774
• 文章类型: Journal Article
• 中科院分区: Q2
• 作者列表: Chen XL,Qin HL

关键词: E-selectivity; SO2F2; direct N–O activation; nitrile synthesis; ring-opening cross-coupling; sulfuryl fluoride

Abstract

A SO2F2-mediated ring-opening cross-coupling of cyclobutanone oxime derivatives with alkenes was developed for the construction of a range of δ-olefin-containing aliphatic nitriles with (E)-configuration selectivity. This new method features wide substrate scope, mild conditions, and direct N-O activation.

摘要

开发了环丁酮肟衍生物与烯烃的SO2F2介导的开环交叉偶联，用于构建一系列具有（E）构型选择性的含δ-烯烃的脂族腈。这种新方法具有广泛的底物范围，温和的条件,和直接的N-O活化。