PDF(Pubmed)
Abstract：
Background and Objectives: Preterm birth, one of the leading causes of neonatal mortality, occurs in between 5 and 18% of births. Premature birth can be induced by a variety of triggers, including infection or inflammation. Serum amyloid A, a family of apolipoproteins, increases significantly and rapidly at the onset of inflammation. This study aims to systematically review the results of studies in the literature that have examined the correlation between SAA and PTB/PROM. Materials and Methods: To examine the correlation between serum amyloid A levels in women who gave birth prematurely, a systematic analysis was performed according to PRISMA guidelines. Studies were retrieved by searching the electronic databases PubMed and Google Scholar. The primary outcome measure was the standardized mean difference in serum amyloid A level comparing the preterm birth or premature rupture of membranes groups and the term birth group. Results: Based on the inclusion criteria, a total of 5 manuscripts adequately addressed the desired outcome and were thus included in the analysis. All included studies showed a statistically significant difference in serum SAA levels between the preterm birth or preterm rupture of membranes groups and the term birth group. The pooled effect, according to the random effects model, is SMD = 2.70. However, the effect is not significant (p = 0.097). In addition, the analysis reveals an increased heterogeneity with an I2 = 96%. Further, the analysis of the influence on heterogeneity found a study that has a significant influence on heterogeneity. However, even after outline exclusion, heterogeneity remained high I2 = 90.7%. Conclusions: There is an association between increased levels of SAA and preterm birth/PROM, but studies have shown great heterogeneity.
摘要：
背景和目的：早产，新生儿死亡的主要原因之一，发生在5％至18％的婴儿中。早产可以由多种触发因素引起，包括感染或炎症。血清淀粉样蛋白A,一个载脂蛋白家族，在炎症发作时显着迅速增加。本研究旨在系统地回顾研究SAA与PTB/PROM之间相关性的文献研究结果。材料和方法:探讨早产妇女血清淀粉样蛋白A水平的相关性,根据PRISMA指南进行系统分析.通过搜索电子数据库PubMed和GoogleScholar来检索研究。主要结局指标是比较早产或胎膜早破组和足月分娩组的血清淀粉样蛋白A水平的标准化平均差异。结果：根据纳入标准，共有5份手稿充分满足了预期结果,因此被纳入分析.所有纳入的研究表明，早产或胎膜早破组与足月分娩组之间的血清SAA水平存在统计学上的显着差异。集合效应，根据随机效应模型，SMD=2.70。然而,效果不显著(p=0.097)。此外,分析显示异质性增加，I2=96%。Further,对异质性影响的分析发现了一项对异质性有显著影响的研究。然而,即使在大纲排除之后，异质性仍然很高，I2=90.7%。结论：SAA水平升高与早产/PROM之间存在关联。但是研究显示出很大的异质性。
