PDF(Pubmed)
Abstract：
Bacterial infections have become a fatal threat because of the abuse of antibiotics in the world. Various gold (Au)-based nanostructures have been extensively explored as antibacterial agents to combat bacterial infections based on their remarkable chemical and physical characteristics. Many Au-based nanostructures have been designed and their antibacterial activities and mechanisms have been further examined and demonstrated. In this review, we collected and summarized current developments of antibacterial agents of Au-based nanostructures, including Au nanoparticles (AuNPs), Au nanoclusters (AuNCs), Au nanorods (AuNRs), Au nanobipyramids (AuNBPs), and Au nanostars (AuNSs) according to their shapes, sizes, and surface modifications. The rational designs and antibacterial mechanisms of these Au-based nanostructures are further discussed. With the developments of Au-based nanostructures as novel antibacterial agents, we also provide perspectives, challenges, and opportunities for future practical clinical applications.
摘要：
由于抗生素在世界范围内的滥用，细菌感染已成为致命的威胁。各种基于金(Au)的纳米结构基于其显著的化学和物理特性作为抗细菌剂被广泛地探索以对抗细菌感染。已经设计了许多基于Au的纳米结构，并进一步研究和证明了它们的抗菌活性和机理。在这次审查中,我们收集和总结了金基纳米结构抗菌剂的发展现状，包括Au纳米颗粒(AuNP)，Au纳米团簇（AuNC），Au纳米棒(AuNRs)Au纳米金字塔（AuNBPs），和金纳米星（AuNSs）根据它们的形状，尺寸,和表面改性。进一步讨论了这些Au基纳米结构的合理设计和抗菌机理。随着Au基纳米结构作为新型抗菌剂的发展，我们还提供观点，挑战,以及未来实际临床应用的机会。
