PDF(Pubmed)
Abstract：
HSPA8 is involved in many stroke-associated cellular processes, playing a pivotal role in the protein quality control system. Here we report the results of the pilot study aimed at determining whether HSPA8 SNPs are linked to the risk of ischemic stroke (IS). DNA samples from 2139 Russians (888 IS patients and 1251 healthy controls) were genotyped for tagSNPs (rs1461496, rs10892958, and rs1136141) in the HSPA8 gene using probe-based PCR. SNP rs10892958 of HSPA8 was associated with an increased risk (risk allele G) of IS in smokers (OR = 1.37; 95% CI = 1.07-1.77; p = 0.01) and patients with low fruit and vegetable consumption (OR = 1.36; 95% CI = 1.14-1.63; p = 0.002). SNP rs1136141 of HSPA8 was also associated with an increased risk of IS (risk allele A) exclusively in smokers (OR = 1.68; 95% CI = 1.23-2.28; p = 0.0007) and in patients with a low fruit and vegetable intake (OR = 1.29; 95% CI = 1.05-1.60; p = 0.04). Sex-stratified analysis revealed an association of rs10892958 HSPA8 with an increased risk of IS in males (risk allele G; OR = 1.30; 95% CI = 1.05-1.61; p = 0.01). Thus, SNPs rs10892958 and rs1136141 in the HSPA8 gene represent novel genetic markers of IS.
摘要：
HSPA8参与许多中风相关的细胞过程，在蛋白质质量控制体系中起着举足轻重的作用。在这里，我们报告了旨在确定HSPA8SNP是否与缺血性卒中（IS）风险相关的初步研究的结果。使用基于探针的PCR，对来自2139名俄罗斯人（888名IS患者和1251名健康对照）的DNA样本进行了HSPA8基因中标签SNP（rs1461496，rs10892958和rs1136141）的基因分型。HSPA8的SNPrs10892958与吸烟者（OR=1.37；95％CI=1.07-1.77；p=0.01）和水果和蔬菜消费量低的患者（OR=1.36；95％CI=1.14-1.63；p=0.002）的IS风险增加有关。HSPA8的SNPrs1136141也与吸烟者（OR=1.68；95％CI=1.23-2.28；p=0.0007）和水果和蔬菜摄入量低的患者（OR=1.29；95％CI=1.05-1.60；p=0.04）的IS（风险等位基因A）风险增加相关。性别分层分析显示rs10892958HSPA8与男性IS风险增加相关(风险等位基因G;OR=1.30;95%CI=1.05-1.61;p=0.01)。因此，HSPA8基因中的SNPsrs10892958和rs1136141代表了IS的新遗传标记。
