PDF(Pubmed)
Abstract：
Burkitt lymphoma (BL) is a form of B-cell malignancy that progresses aggressively and is most often seen in children. While Epstein-Barr virus (EBV) is a double-stranded DNA virus that has been linked to a variety of cancers, it can transform B lymphocytes into immortalized cells, as shown in BL. Therefore, the estimated prevalence of EBV in a population may assist in the prediction of whether this population has a high risk of increased BL cases. This systematic review and meta-analysis aimed to estimate the prevalence of Epstein-Barr virus in patients with Burkitt lymphoma. Using the appropriate keywords, four electronic databases were searched. The quality of the included studies was assessed using the Joanna Briggs Institute\'s critical appraisal tool. The results were reported as percentages with a 95% confidence interval using a random-effects model (CI). PROSPERO was used to register the protocol (CRD42022372293), and 135 studies were included. The prevalence of Epstein-Barr virus in patients with Burkitt lymphoma was 57.5% (95% CI: 51.5 to 63.4, n = 4837). The sensitivity analyses demonstrated consistent results, and 65.2% of studies were of high quality. Egger\'s test revealed that there was a significant publication bias. EBV was found in a significantly high proportion of BL patients (more than 50% of BL patients). This study recommends EBV testing as an alternative for predictions and the assessment of the clinical disease status of BL.
摘要：
伯基特淋巴瘤（BL）是B细胞恶性肿瘤的一种形式，其进展迅速，最常见于儿童。虽然爱泼斯坦-巴尔病毒（EBV）是一种双链DNA病毒，与多种癌症有关，它可以将B淋巴细胞转化为永生化的细胞，如BL所示。因此,人群中EBV的估计患病率可能有助于预测该人群是否有高BL病例增加的风险.本系统评价和荟萃分析旨在评估伯基特淋巴瘤患者中EB病毒的患病率。使用适当的关键字，搜索了四个电子数据库。纳入研究的质量使用JoannaBriggs研究所的关键评估工具进行评估。使用随机效应模型（CI）将结果报告为百分比，置信区间为95％。PROSPERO用于注册协议（CRD42022372293），共纳入135项研究。伯基特淋巴瘤患者中EB病毒的患病率为57.5%(95%CI:51.5~63.4,n=4837)。敏感性分析显示出一致的结果，65.2%的研究是高质量的。Egger的测试显示，存在明显的出版偏见。在BL患者中发现EBV的比例很高（超过50％的BL患者）。这项研究建议EBV测试作为预测和评估BL临床疾病状态的替代方法。
