PDF(Pubmed)
Abstract：
The transcription factor runt-related protein (RUNX) family is the major transcription factor responsible for the formation of osteoblasts from bone marrow mesenchymal stem cells, which are involved in bone formation. Accumulating evidence implicates the RUNX family for its role in tumor biology and cancer progression. The RUNX family has been linked to osteosarcoma via its regulation of many tumorigenicity-related factors. In the regulatory network of cancers, with numerous upstream signaling pathways and its potential target molecules downstream, RUNX is a vital molecule. Hence, a pressing need exists to understand the precise process underpinning the occurrence and prognosis of several malignant tumors. Until recently, RUNX has been regarded as one of the therapeutic targets for bone cancer. Therefore, in this review, we have provided insights into various molecular mechanisms behind the tumorigenic role of RUNX in various important cancers. RUNX is anticipated to grow into a novel therapeutic target with the in-depth study of RUNX family-related regulatory processes, aid in the creation of new medications, and enhance clinical efficacy.
摘要：
转录因子runt相关蛋白(RUNX)家族是骨髓间充质干细胞形成成骨细胞的主要转录因子,参与骨形成。越来越多的证据表明RUNX家族在肿瘤生物学和癌症进展中的作用。RUNX家族通过调节许多致瘤性相关因子与骨肉瘤有关。在癌症的监管网络中，具有许多上游信号通路及其下游潜在的靶分子，RUNX是一种重要的分子。因此，迫切需要了解支持几种恶性肿瘤发生和预后的精确过程。直到最近,RUNX已被视为骨癌的治疗靶标之一。因此,在这次审查中,我们对RUNX在各种重要癌症中的致瘤作用背后的各种分子机制提供了见解.随着对RUNX家族相关调控过程的深入研究，RUNX有望成长为一个新的治疗靶点。帮助创造新的药物，提高临床疗效。
