Abstract：
BACKGROUND: Enteral nutrition (EN) assists in the nutritional status of hospitalised patients unable to feed orally. The aim of this study was to determine which method-continuous EN or discontinuous EN, a diet in which the infusion is discontinued for 4h during the night,-is more effective in meeting nutrient recommendations and improving glycaemic control and biochemical parameters related to protein anabolism.
METHODS: Patients were divided into two groups: discontinuous (EN administered in mL/h, 18h/day, 4-h night fasting) and continuous (EN administered in mL/h, 22h/day). All patients with EN receive the diet over a 22-h daily period, in which the diet is suspended for two hours/day for daily hospital routines such as bathing, and physiotherapy, and followed for seven days. Evaluated data: prescribed and administered volume, calories, protein, and fibre; capillary blood glucose; erythrogram; serum albumin.
RESULTS: 52 patients were followed-up, with 23 (44.2%) in the discontinuous group and 29 (55.8%) in the continuous group. Compared with the continuous group, the discontinuous group received volumes closer to those prescribed, equal or higher calories, and more protein. The capillary glucose values were within the reference range in the discontinuous group, while the continuous group presented elevated values. Both groups presented hypoalbuminaemia, haemoglobin, and haematocrit below the reference values; however, in the discontinuous group, the serum albumin values improved during hospitalisation relative to the continuous.
CONCLUSIONS: The method involving discontinuation of EN for 4h was more effective in meeting nutrient recommendations compared with the continuous method. Additionally, in the discontinuous group, we observed a better control of glycaemia when compared to that of the continuous group.
METHODS: Patients were divided into two groups: discontinuous (EN administered in mL/h, 18h/day, 4-h night fasting) and continuous (EN administered in mL/h, 22h/day). All patients with EN receive the diet over a 22-h daily period, in which the diet is suspended for two hours/day for daily hospital routines such as bathing, and physiotherapy, and followed for seven days. Evaluated data: prescribed and administered volume, calories, protein, and fibre; capillary blood glucose; erythrogram; serum albumin.
RESULTS: 52 patients were followed-up, with 23 (44.2%) in the discontinuous group and 29 (55.8%) in the continuous group. Compared with the continuous group, the discontinuous group received volumes closer to those prescribed, equal or higher calories, and more protein. The capillary glucose values were within the reference range in the discontinuous group, while the continuous group presented elevated values. Both groups presented hypoalbuminaemia, haemoglobin, and haematocrit below the reference values; however, in the discontinuous group, the serum albumin values improved during hospitalisation relative to the continuous.
CONCLUSIONS: The method involving discontinuation of EN for 4h was more effective in meeting nutrient recommendations compared with the continuous method. Additionally, in the discontinuous group, we observed a better control of glycaemia when compared to that of the continuous group.
摘要：
背景：肠内营养（EN）有助于无法口服喂养的住院患者的营养状况。这项研究的目的是确定哪种方法-连续EN或不连续EN，在夜间停止输注4h的饮食，-在满足营养建议和改善与蛋白质合成代谢相关的血糖控制和生化参数方面更有效。
方法：患者分为两组：不连续（EN以mL/h为单位，18h/天,4小时夜间禁食）和连续（EN以mL/h为单位，22h/天)。所有患有EN的患者每天接受22小时的饮食，在这种情况下，每天停止饮食两小时，以进行日常医院工作，例如洗澡，和物理治疗，跟踪了七天.评估数据：处方和给药体积，卡路里,蛋白质，和纤维；毛细血管血糖；红细胞图；血清白蛋白。
结果：52例患者获得随访，不连续组23例（44.2%），连续组29例（55.8%）。与连续组相比，不连续组收到的音量更接近处方，相等或更高的卡路里，更多的蛋白质不连续组毛细血管血糖值在参考范围内，而连续组呈现升高的值。两组均出现低白蛋白血症,血红蛋白，和血细胞比容低于参考值；然而，在不连续组中，相对于连续治疗,住院期间血清白蛋白值有所改善.
结论：与连续方法相比，包括停用EN4h的方法更有效地满足营养建议。此外,在不连续组中，与连续组相比，我们观察到血糖控制更好。
方法：患者分为两组：不连续（EN以mL/h为单位，18h/天,4小时夜间禁食）和连续（EN以mL/h为单位，22h/天)。所有患有EN的患者每天接受22小时的饮食，在这种情况下，每天停止饮食两小时，以进行日常医院工作，例如洗澡，和物理治疗，跟踪了七天.评估数据：处方和给药体积，卡路里,蛋白质，和纤维；毛细血管血糖；红细胞图；血清白蛋白。
结果：52例患者获得随访，不连续组23例（44.2%），连续组29例（55.8%）。与连续组相比，不连续组收到的音量更接近处方，相等或更高的卡路里，更多的蛋白质不连续组毛细血管血糖值在参考范围内，而连续组呈现升高的值。两组均出现低白蛋白血症,血红蛋白，和血细胞比容低于参考值；然而，在不连续组中，相对于连续治疗,住院期间血清白蛋白值有所改善.
结论：与连续方法相比，包括停用EN4h的方法更有效地满足营养建议。此外,在不连续组中，与连续组相比，我们观察到血糖控制更好。
