Abstract：
OBJECTIVE: To characterize the presentation and treatment of children presenting with primary salivary gland neoplasms.
METHODS: A retrospective review of primary salivary tumor patients presenting to Children\'s Hospital Colorado between January 2000 and August 2020.
RESULTS: Fifty children were identified with primary salivary gland tumors, comprising of 39 (78 %) benign and 11 (22 %) malignant lesions. Pleomorphic adenoma was the most common benign tumor (36/39, 92 %), while acinic cell carcinoma was the most common malignancy (7/11, 64 %). The parotid gland was the most common site, followed by the submandibular gland (66 % vs. 34 %). No tumors were found in the sublingual glands. Benign neoplasms accounted for 70 % of parotid lesions and 94 % of submandibular tumors. No significant differences in age (13.6 years, SD 4 vs. 13.0 years, SD 4.3) were noted between patients with benign and malignant disease, but tumors in females were more frequently malignant (M:F 1:1.3 vs. 1:2.7 for benign and malignant tumors, respectively). Neck dissection and/or facial nerve sacrifice were required in 27 % (3/11) and 9.1 % (1/11) of malignancies, respectively. Local recurrence was observed in 7.7 % (3/39) of benign cases and 9.1 % (1/11) of malignant cases. No salivary malignancies required chemotherapy, though one patient with neurofibromatosis received imatinib prior to resection. Two patients with locoregional malignancy received adjunctive radiation. The average duration of follow up for benign and malignant disease were 12.6 ± 25 and 45.1 ± 32 months, respectively.
CONCLUSIONS: This study presents one of the larger single institutional experiences of pediatric primary salivary neoplasms in the past 20 years, identifying pleomorphic adenoma and acinic cell carcinoma as the most common benign and malignant etiologies, respectively. While this review found most neoplasms presented as a localized mass effectively managed with conservative surgical resection, aggressive tumors required multidisciplinary care.
METHODS: A retrospective review of primary salivary tumor patients presenting to Children\'s Hospital Colorado between January 2000 and August 2020.
RESULTS: Fifty children were identified with primary salivary gland tumors, comprising of 39 (78 %) benign and 11 (22 %) malignant lesions. Pleomorphic adenoma was the most common benign tumor (36/39, 92 %), while acinic cell carcinoma was the most common malignancy (7/11, 64 %). The parotid gland was the most common site, followed by the submandibular gland (66 % vs. 34 %). No tumors were found in the sublingual glands. Benign neoplasms accounted for 70 % of parotid lesions and 94 % of submandibular tumors. No significant differences in age (13.6 years, SD 4 vs. 13.0 years, SD 4.3) were noted between patients with benign and malignant disease, but tumors in females were more frequently malignant (M:F 1:1.3 vs. 1:2.7 for benign and malignant tumors, respectively). Neck dissection and/or facial nerve sacrifice were required in 27 % (3/11) and 9.1 % (1/11) of malignancies, respectively. Local recurrence was observed in 7.7 % (3/39) of benign cases and 9.1 % (1/11) of malignant cases. No salivary malignancies required chemotherapy, though one patient with neurofibromatosis received imatinib prior to resection. Two patients with locoregional malignancy received adjunctive radiation. The average duration of follow up for benign and malignant disease were 12.6 ± 25 and 45.1 ± 32 months, respectively.
CONCLUSIONS: This study presents one of the larger single institutional experiences of pediatric primary salivary neoplasms in the past 20 years, identifying pleomorphic adenoma and acinic cell carcinoma as the most common benign and malignant etiologies, respectively. While this review found most neoplasms presented as a localized mass effectively managed with conservative surgical resection, aggressive tumors required multidisciplinary care.
摘要：
目的：探讨原发性唾液腺肿瘤患儿的表现和治疗。
方法：回顾性回顾了2000年1月至2020年8月在科罗拉多州儿童医院就诊的原发性唾液肿瘤患者。
结果：50名儿童被确定为原发性唾液腺肿瘤，包括39个（78%）良性病变和11个（22%）恶性病变。多形性腺瘤是最常见的良性肿瘤（36/39，92%），而腺泡细胞癌是最常见的恶性肿瘤（7/11，64％）。腮腺是最常见的部位,其次是颌下腺(66%vs.34%)。舌下腺中未发现肿瘤。良性肿瘤占腮腺病变的70％，占下颌下肿瘤的94％。年龄无显著差异（13.6岁，SD4vs.13.0年,SD4.3)记录在良性和恶性疾病患者之间，但女性肿瘤更常见的是恶性(M：F1：1.3与良性和恶性肿瘤1:2.7，分别)。27％（3/11）和9.1％（1/11）的恶性肿瘤需要颈部解剖和/或面部神经损伤，分别。良性病例占7.7％（3/39），恶性病例占9.1％（1/11）。没有唾液恶性肿瘤需要化疗，尽管一名神经纤维瘤病患者在切除前接受了伊马替尼治疗。两名局部恶性肿瘤患者接受了辅助放疗。良性和恶性疾病的平均随访时间为12.6±25和45.1±32个月。分别。
结论：这项研究提出了过去20年中儿科原发性唾液肿瘤的较大单一机构经验之一，确定多形性腺瘤和腺泡细胞癌为最常见的良性和恶性病因，分别。虽然这篇综述发现大多数肿瘤表现为局部肿块，但通过保守手术切除有效治疗，侵袭性肿瘤需要多学科护理。
方法：回顾性回顾了2000年1月至2020年8月在科罗拉多州儿童医院就诊的原发性唾液肿瘤患者。
结果：50名儿童被确定为原发性唾液腺肿瘤，包括39个（78%）良性病变和11个（22%）恶性病变。多形性腺瘤是最常见的良性肿瘤（36/39，92%），而腺泡细胞癌是最常见的恶性肿瘤（7/11，64％）。腮腺是最常见的部位,其次是颌下腺(66%vs.34%)。舌下腺中未发现肿瘤。良性肿瘤占腮腺病变的70％，占下颌下肿瘤的94％。年龄无显著差异（13.6岁，SD4vs.13.0年,SD4.3)记录在良性和恶性疾病患者之间，但女性肿瘤更常见的是恶性(M：F1：1.3与良性和恶性肿瘤1:2.7，分别)。27％（3/11）和9.1％（1/11）的恶性肿瘤需要颈部解剖和/或面部神经损伤，分别。良性病例占7.7％（3/39），恶性病例占9.1％（1/11）。没有唾液恶性肿瘤需要化疗，尽管一名神经纤维瘤病患者在切除前接受了伊马替尼治疗。两名局部恶性肿瘤患者接受了辅助放疗。良性和恶性疾病的平均随访时间为12.6±25和45.1±32个月。分别。
结论：这项研究提出了过去20年中儿科原发性唾液肿瘤的较大单一机构经验之一，确定多形性腺瘤和腺泡细胞癌为最常见的良性和恶性病因，分别。虽然这篇综述发现大多数肿瘤表现为局部肿块，但通过保守手术切除有效治疗，侵袭性肿瘤需要多学科护理。
