PDF(Pubmed)
Abstract：
UNASSIGNED: The purpose of this study was to examine the extent of the literature on the neurophysiological lesion as referenced in functional neurology.
UNASSIGNED: A literature search was performed within the period from 2010 to March 2021. Search terms included central sensitization, central sensitivity syndrome, nociplastic pain, cold hyperalgesia, heat hyperalgesia, mechanical hyperalgesia, dynamic mechanical allodynia, temporal summation, spatial summation, and descending inhibition. A qualitative synthesis summarized the research findings, including clinical conditions and effect of spinal manipulation.
UNASSIGNED: There were 30 studies, which included 7 high-level studies (meta-analysis or systematic reviews), 22 randomized controlled studies, and 1 scoping review. The findings suggest the existence of the changes in the central integrated state of a population of neurons with various disorders, experimentally induced stimulation, and treatment. The current literature suggests plasticity of the central integrative state (CIS) with the onset of pathologies and the changes in the CIS with different conservative nonpharmacologic treatments.
UNASSIGNED: This review suggests changes in the resting state of the CIS of a population of neurons that exist in the physiologic lesion may change in response to various therapies, including manipulative therapy. The findings from this review provide support of the hypothesis that nonpharmacologic conservative care may affect the neurophysiological lesion. However, studies were heterogeneous and evidence was lacking in the translation of targeting the therapies to distinct neuronal areas for clinical outcomes to treat specific disease states.
UNASSIGNED: A literature search was performed within the period from 2010 to March 2021. Search terms included central sensitization, central sensitivity syndrome, nociplastic pain, cold hyperalgesia, heat hyperalgesia, mechanical hyperalgesia, dynamic mechanical allodynia, temporal summation, spatial summation, and descending inhibition. A qualitative synthesis summarized the research findings, including clinical conditions and effect of spinal manipulation.
UNASSIGNED: There were 30 studies, which included 7 high-level studies (meta-analysis or systematic reviews), 22 randomized controlled studies, and 1 scoping review. The findings suggest the existence of the changes in the central integrated state of a population of neurons with various disorders, experimentally induced stimulation, and treatment. The current literature suggests plasticity of the central integrative state (CIS) with the onset of pathologies and the changes in the CIS with different conservative nonpharmacologic treatments.
UNASSIGNED: This review suggests changes in the resting state of the CIS of a population of neurons that exist in the physiologic lesion may change in response to various therapies, including manipulative therapy. The findings from this review provide support of the hypothesis that nonpharmacologic conservative care may affect the neurophysiological lesion. However, studies were heterogeneous and evidence was lacking in the translation of targeting the therapies to distinct neuronal areas for clinical outcomes to treat specific disease states.
摘要：
■这项研究的目的是检查有关功能神经病学中神经生理学病变的文献的范围。
■在2010年至2021年3月期间进行了文献检索。搜索词包括中央宣传，中枢敏感综合征,伤害性疼痛,冷痛觉过敏，热痛觉过敏，机械性痛觉过敏,动态机械性异常性疼痛,时间求和，空间求和，和下降抑制。定性综合总结了研究成果，包括脊柱操作的临床状况和效果。
■有30项研究，其中包括7项高水平研究(荟萃分析或系统评价)，22项随机对照研究，和1个范围审查。研究结果表明，患有各种疾病的神经元群体的中枢整合状态存在变化，实验诱导刺激，和治疗。目前的文献表明，中枢整合状态（CIS）的可塑性随病理的发作以及不同保守非药物治疗的CIS的变化。
■这篇综述表明，在生理病变中存在的神经元群体的CIS的静息状态的变化可能会响应于各种疗法而发生变化，包括手法治疗.这篇综述的发现为非药物保守治疗可能影响神经生理学病变的假设提供了支持。然而,研究存在异质性,缺乏将疗法靶向不同神经元区域以获得治疗特定疾病状态的临床结果的证据.
■在2010年至2021年3月期间进行了文献检索。搜索词包括中央宣传，中枢敏感综合征,伤害性疼痛,冷痛觉过敏，热痛觉过敏，机械性痛觉过敏,动态机械性异常性疼痛,时间求和，空间求和，和下降抑制。定性综合总结了研究成果，包括脊柱操作的临床状况和效果。
■有30项研究，其中包括7项高水平研究(荟萃分析或系统评价)，22项随机对照研究，和1个范围审查。研究结果表明，患有各种疾病的神经元群体的中枢整合状态存在变化，实验诱导刺激，和治疗。目前的文献表明，中枢整合状态（CIS）的可塑性随病理的发作以及不同保守非药物治疗的CIS的变化。
■这篇综述表明，在生理病变中存在的神经元群体的CIS的静息状态的变化可能会响应于各种疗法而发生变化，包括手法治疗.这篇综述的发现为非药物保守治疗可能影响神经生理学病变的假设提供了支持。然而,研究存在异质性,缺乏将疗法靶向不同神经元区域以获得治疗特定疾病状态的临床结果的证据.
