Abstract：
The electiveness of Capsicum annuum supplementation in controlling dyslipidemia in adults has been unclear. Therefore, this meta-analysis focuses on the relationship between C. annuum supplementation and lipid profile in adults with metabolic syndrome (MetS) and related disorders. PubMed, Scopus, ISI Web of Science, and the Cochrane Library were searched up to March 2021. Only randomized controlled trials (RCTs) studying the administration of C. annuum compared to control on lipid markers in adults with MetS and related disorders were examined. Pooled effect sizes were reported as weighted mean differences (WMDs) and 95% confidence intervals (CIs). The results of four eligible RCTs showed that C. annuum supplementation could significantly reduce total cholesterol (TC) (WMD: -4.98 mg/dL, 95% CI: -7.08 to -2.88, p ≤ 0.001) levels, but did not regulate triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol concentrations. In summary, the present findings suggest the beneficial effects of C. annuum supplementation on the reduction of plasma levels of TC. However, to draw a firm link between C. annuum supplementation and lipid profile, more trials with adequate sample sizes, specifically in subjects with dyslipidemia are warranted.
摘要：
目前尚不清楚补充辣椒在控制成人血脂异常中的选择性。因此,本荟萃分析的重点是成人代谢综合征(MetS)及相关疾病患者补充C.annuum与血脂谱之间的关系.PubMed,Scopus,ISIWebofScience,和Cochrane图书馆被搜索到2021年3月。仅研究了随机对照试验（RCTs），该试验研究了C.annuum的给药方式，与MetS成人和相关疾病患者的脂质标志物对照相比。汇总效应大小报告为加权平均差(WMD)和95%置信区间(CI)。四个合格的随机对照试验结果表明，补充C.annuum可以显着降低总胆固醇（TC）（WMD：-4.98mg/dL，95%CI：-7.08至-2.88，p≤0.001）水平，但不调节甘油三酯，高密度脂蛋白胆固醇，和低密度脂蛋白胆固醇浓度。总之,本研究结果表明，补充C.annuum对降低血浆TC水平具有有益作用。然而,为了在C.annuum补充剂和脂质分布之间建立牢固的联系，有足够样本量的更多试验，特别是在血脂异常的受试者中是有保证的。
