METHODS: Data of this retrospective cohort study were obtained from the National Vital Statistics System (NVSS) 2020. The participants were divided into different groups according to different IPI (<6, 6-11, 12-17, 18-23, 24-59 (reference), 60-119, ≥120 months). Multivariate logistic models were constructed to evaluate the association between IPI and GDM. Subgroup analysis was further performed.
RESULTS: A total of 1 515 263 women were included, with 123 951 (8.18%) having GDM. Compared with the 24-59 months group, the <6 months (odds ratio [OR] 0.64, 95% confidence interval [CI] 0.46-0.90, P = 0.009), 12-17 months (OR 0.96, 95% CI 0.94-0.98, P < 0.001), and 18-23 months (OR 0.94, 95% CI 0.93-0.96, P < 0.001) groups had a significantly lower risk of GDM, while the 60-119 months (OR 1.13, 95% CI 1.11-1.15, P < 0.001) and ≥120 months (OR 1.18, 95% CI 1.15-1.21, P < 0.001) groups had a significantly higher risk of GDM. No significant difference was observed in the risk of GDM between the 6-11 and 24-59 months groups (P = 0.542). The PI-GDM association varied across different groups of age, pre-pregnancy body mass index, pre-pregnancy smoking status, history of cesarean section, history of preterm birth, prior terminations, and parity.
CONCLUSIONS: An IPI of 18-23 months may be a better interval than 24-59 months in managing the risk of GDM.
方法:这项回顾性队列研究的数据来自国家生命统计系统(NVSS)2020。根据不同的IPI将参与者分为不同的组(<6、6-11、12-17、18-23、24-59(参考),60-119,≥120个月)。建立多变量Logistic模型来评估IPI和GDM之间的相关性。进一步进行亚组分析。
结果:共纳入1515263名妇女,123951(8.18%)患有GDM。与24-59个月组相比,<6个月(比值比[OR]0.64,95%置信区间[CI]0.46-0.90,P=0.009),12-17个月(OR0.96,95%CI0.94-0.98,P<0.001),和18-23个月(OR0.94,95%CI0.93-0.96,P<0.001)组GDM的风险显着降低,而60-119个月(OR1.13,95%CI1.11-1.15,P<0.001)和≥120个月(OR1.18,95%CI1.15-1.21,P<0.001)组的GDM风险显着升高。在6-11和24-59个月组之间,GDM的风险没有显着差异(P=0.542)。PI-GDM关联在不同年龄段有所不同,孕前体重指数,怀孕前吸烟状况,剖宫产史,早产史,先前的终止,和平价。
结论:在控制GDM风险方面,18-23个月的IPI可能比24-59个月更好。