Abstract：
OBJECTIVE: To assess the association between interpregnancy interval (IPI) and gestational diabetes mellitus (GDM).
METHODS: Data of this retrospective cohort study were obtained from the National Vital Statistics System (NVSS) 2020. The participants were divided into different groups according to different IPI (<6, 6-11, 12-17, 18-23, 24-59 (reference), 60-119, ≥120 months). Multivariate logistic models were constructed to evaluate the association between IPI and GDM. Subgroup analysis was further performed.
RESULTS: A total of 1 515 263 women were included, with 123 951 (8.18%) having GDM. Compared with the 24-59 months group, the <6 months (odds ratio [OR] 0.64, 95% confidence interval [CI] 0.46-0.90, P = 0.009), 12-17 months (OR 0.96, 95% CI 0.94-0.98, P < 0.001), and 18-23 months (OR 0.94, 95% CI 0.93-0.96, P < 0.001) groups had a significantly lower risk of GDM, while the 60-119 months (OR 1.13, 95% CI 1.11-1.15, P < 0.001) and ≥120 months (OR 1.18, 95% CI 1.15-1.21, P < 0.001) groups had a significantly higher risk of GDM. No significant difference was observed in the risk of GDM between the 6-11 and 24-59 months groups (P = 0.542). The PI-GDM association varied across different groups of age, pre-pregnancy body mass index, pre-pregnancy smoking status, history of cesarean section, history of preterm birth, prior terminations, and parity.
CONCLUSIONS: An IPI of 18-23 months may be a better interval than 24-59 months in managing the risk of GDM.
METHODS: Data of this retrospective cohort study were obtained from the National Vital Statistics System (NVSS) 2020. The participants were divided into different groups according to different IPI (<6, 6-11, 12-17, 18-23, 24-59 (reference), 60-119, ≥120 months). Multivariate logistic models were constructed to evaluate the association between IPI and GDM. Subgroup analysis was further performed.
RESULTS: A total of 1 515 263 women were included, with 123 951 (8.18%) having GDM. Compared with the 24-59 months group, the <6 months (odds ratio [OR] 0.64, 95% confidence interval [CI] 0.46-0.90, P = 0.009), 12-17 months (OR 0.96, 95% CI 0.94-0.98, P < 0.001), and 18-23 months (OR 0.94, 95% CI 0.93-0.96, P < 0.001) groups had a significantly lower risk of GDM, while the 60-119 months (OR 1.13, 95% CI 1.11-1.15, P < 0.001) and ≥120 months (OR 1.18, 95% CI 1.15-1.21, P < 0.001) groups had a significantly higher risk of GDM. No significant difference was observed in the risk of GDM between the 6-11 and 24-59 months groups (P = 0.542). The PI-GDM association varied across different groups of age, pre-pregnancy body mass index, pre-pregnancy smoking status, history of cesarean section, history of preterm birth, prior terminations, and parity.
CONCLUSIONS: An IPI of 18-23 months may be a better interval than 24-59 months in managing the risk of GDM.
摘要：
目的：评估妊娠间期（IPI）与妊娠期糖尿病（GDM）的关系。
方法：这项回顾性队列研究的数据来自国家生命统计系统（NVSS）2020。根据不同的IPI将参与者分为不同的组（<6、6-11、12-17、18-23、24-59（参考），60-119，≥120个月）。建立多变量Logistic模型来评估IPI和GDM之间的相关性。进一步进行亚组分析。
结果：共纳入1515263名妇女，123951（8.18%）患有GDM。与24-59个月组相比，<6个月(比值比[OR]0.64，95%置信区间[CI]0.46-0.90，P=0.009)，12-17个月（OR0.96，95％CI0.94-0.98，P<0.001），和18-23个月（OR0.94，95％CI0.93-0.96，P<0.001）组GDM的风险显着降低，而60-119个月（OR1.13，95％CI1.11-1.15，P<0.001）和≥120个月（OR1.18，95％CI1.15-1.21，P<0.001）组的GDM风险显着升高。在6-11和24-59个月组之间，GDM的风险没有显着差异（P=0.542）。PI-GDM关联在不同年龄段有所不同，孕前体重指数,怀孕前吸烟状况,剖宫产史,早产史,先前的终止，和平价。
结论：在控制GDM风险方面，18-23个月的IPI可能比24-59个月更好。
方法：这项回顾性队列研究的数据来自国家生命统计系统（NVSS）2020。根据不同的IPI将参与者分为不同的组（<6、6-11、12-17、18-23、24-59（参考），60-119，≥120个月）。建立多变量Logistic模型来评估IPI和GDM之间的相关性。进一步进行亚组分析。
结果：共纳入1515263名妇女，123951（8.18%）患有GDM。与24-59个月组相比，<6个月(比值比[OR]0.64，95%置信区间[CI]0.46-0.90，P=0.009)，12-17个月（OR0.96，95％CI0.94-0.98，P<0.001），和18-23个月（OR0.94，95％CI0.93-0.96，P<0.001）组GDM的风险显着降低，而60-119个月（OR1.13，95％CI1.11-1.15，P<0.001）和≥120个月（OR1.18，95％CI1.15-1.21，P<0.001）组的GDM风险显着升高。在6-11和24-59个月组之间，GDM的风险没有显着差异（P=0.542）。PI-GDM关联在不同年龄段有所不同，孕前体重指数,怀孕前吸烟状况,剖宫产史,早产史,先前的终止，和平价。
结论：在控制GDM风险方面，18-23个月的IPI可能比24-59个月更好。
