PDF(Pubmed)
Abstract：
Coping with a chronic disease such as rheumatoid arthritis (RA) involves significant changes in life and promotes stressful situations. The inability to cope with stress can contribute to the lack of effectiveness of therapy. The aim of this study was to evaluate the relationship between perceived stress, coping strategies, and the clinical status of RA patients determined by C-reactive protein (CRP) and Disease Activity Score (DAS28). 165 subjects were studied, 84 of them had RA and the rest were controls. Standardised questionnaires were used: the Inventory for the Measurement of Coping Strategies (Mini-COPE) and the Perceived Stress Scale (PSS-10). A self-administered questionnaire was used to collect sociodemographic data. The blood levels of protein CRP and cortisol were determined. DAS28 was obtained from medical records. The study was cross-sectional. The mean severity of perceived stress PSS-10 was not significantly different between the control and study groups. RA patients most often used coping strategies such as active coping, planning, and acceptance. Compared to the control group, they used the strategy of turning to religion significantly more often (1.8 vs 1.4; p = 0.012). Women with RA who had higher cortisol levels were more likely to use positive reevaluation, seeking emotional support and instrumental support, as well as the denial strategy. In men with RA, high stress was associated with twice as high CRP levels compared to patients with low stress (p = 0.038). As the levels of CRP protein levels (p = 0.009) and the DAS28 index (p = 0.005) increased, patients were more likely to use a denial strategy.
摘要：
应对慢性疾病如类风湿性关节炎（RA）涉及生活中的重大变化并促进压力情况。无法应对压力可能导致治疗缺乏有效性。这项研究的目的是评估感知压力之间的关系，应对策略，通过C反应蛋白（CRP）和疾病活动评分（DAS28）确定RA患者的临床状况。研究了165名受试者，其中84人患有RA，其余为对照。使用标准化问卷：应对策略测量清单（Mini-COPE）和感知压力量表（PSS-10）。使用自我管理的问卷来收集社会人口统计数据。测定血蛋白CRP和皮质醇水平。DAS28来自医疗记录。这项研究是横断面的。对照组和研究组之间感知压力PSS-10的平均严重程度没有显着差异。RA患者最常使用的应对策略，如积极应对，规划,和接受。与对照组相比,他们使用更频繁地转向宗教的策略（1.8vs1.4；p=0.012）。皮质醇水平较高的RA女性更有可能使用积极的重新评估，寻求情感支持和工具支持，以及否认策略。在患有RA的男性中，与低应激患者相比,高应激患者的CRP水平高2倍(p=0.038).随着CRP蛋白水平（p=0.009）和DAS28指数（p=0.005）的增加，患者更有可能使用否认策略.
