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Abstract：
BACKGROUND: The purpose of this study was to compare the characteristics of filtering bleb with anterior segment optical coherence tomography (AS-OCT) according to amniotic membrane transplantation (AMT).
METHODS: One hundred and sixteen eyes of 103 glaucoma patients who underwent trabeculectomy with (AMT group; 85 eyes) or without AMT (control group; 31 eyes) were included. Intrableb parameters were evaluated with AS-OCT. Surgical success was defined as an intraocular pressure (IOP) ≤18 mm Hg and IOP reduction ≥20% without medication at the time of AS-OCT examination. Logistic regression analyses were performed to determine factors associated with IOP control.
RESULTS: In the eyes with successful IOP control, the fluid-filled space area, score, and height were greater for the AMT group than the control group (all ps < 0.001), while stripping layer thickness was greater and bleb wall reflectivity was lower for the control group than the AMT group (all ps < 0.001). Surgical success in the AMT group was associated with greater fluid-filled space score, lower bleb wall reflectivity, and microcyst formation (odds ratio [OR] = 8.016, 0.913, and 16.202, respectively, all ps ≤ 0.041). Lower bleb wall reflectivity alone was associated with surgical success in the control group (OR = 0.815, p = 0.019).
CONCLUSIONS: The extent of the fluid-filled space was associated with successful IOP control after trabeculectomy with AMT. Hyporeflective bleb wall was associated with successful IOP control in AMT and control groups.
METHODS: One hundred and sixteen eyes of 103 glaucoma patients who underwent trabeculectomy with (AMT group; 85 eyes) or without AMT (control group; 31 eyes) were included. Intrableb parameters were evaluated with AS-OCT. Surgical success was defined as an intraocular pressure (IOP) ≤18 mm Hg and IOP reduction ≥20% without medication at the time of AS-OCT examination. Logistic regression analyses were performed to determine factors associated with IOP control.
RESULTS: In the eyes with successful IOP control, the fluid-filled space area, score, and height were greater for the AMT group than the control group (all ps < 0.001), while stripping layer thickness was greater and bleb wall reflectivity was lower for the control group than the AMT group (all ps < 0.001). Surgical success in the AMT group was associated with greater fluid-filled space score, lower bleb wall reflectivity, and microcyst formation (odds ratio [OR] = 8.016, 0.913, and 16.202, respectively, all ps ≤ 0.041). Lower bleb wall reflectivity alone was associated with surgical success in the control group (OR = 0.815, p = 0.019).
CONCLUSIONS: The extent of the fluid-filled space was associated with successful IOP control after trabeculectomy with AMT. Hyporeflective bleb wall was associated with successful IOP control in AMT and control groups.
摘要：
背景：这项研究的目的是根据羊膜移植（AMT）比较滤过泡与眼前节光学相干断层扫描（AS-OCT）的特征。
方法：纳入103例接受小梁切除术的青光眼患者（AMT组；85只眼）或不接受AMT（对照组；31只眼）。使用AS-OCT评估内带参数。手术成功定义为在AS-OCT检查时无药物治疗的情况下眼内压（IOP）≤18mmHg且IOP降低≥20%。进行Logistic回归分析以确定与IOP控制相关的因素。
结果：在成功控制IOP的眼睛中，充满流体的空间区域，得分,AMT组的身高和身高均大于对照组（所有ps＆lt;0.001），与AMT组相比，对照组的剥离层厚度更大，气泡壁反射率更低（所有ps＆lt;0.001）。AMT组的手术成功与更大的充满液体的空间评分相关。较低的气泡壁反射率，和微囊肿形成（比值比[OR]分别=8.016、0.913和16.202，所有ps≤0.041)。在对照组中，较低的泡壁反射率与手术成功相关（OR=0.815，p=0.019）。
结论：AMT小梁切除术后液体填充空间的范围与成功控制IOP相关。在AMT和对照组中，低反射泡壁与成功控制IOP相关。
方法：纳入103例接受小梁切除术的青光眼患者（AMT组；85只眼）或不接受AMT（对照组；31只眼）。使用AS-OCT评估内带参数。手术成功定义为在AS-OCT检查时无药物治疗的情况下眼内压（IOP）≤18mmHg且IOP降低≥20%。进行Logistic回归分析以确定与IOP控制相关的因素。
结果：在成功控制IOP的眼睛中，充满流体的空间区域，得分,AMT组的身高和身高均大于对照组（所有ps＆lt;0.001），与AMT组相比，对照组的剥离层厚度更大，气泡壁反射率更低（所有ps＆lt;0.001）。AMT组的手术成功与更大的充满液体的空间评分相关。较低的气泡壁反射率，和微囊肿形成（比值比[OR]分别=8.016、0.913和16.202，所有ps≤0.041)。在对照组中，较低的泡壁反射率与手术成功相关（OR=0.815，p=0.019）。
结论：AMT小梁切除术后液体填充空间的范围与成功控制IOP相关。在AMT和对照组中，低反射泡壁与成功控制IOP相关。
