PDF(Pubmed)
Abstract：
Bone tumor has become a common disease that endangers human health. Surgical resection of bone tumors not only causes biomechanical defects of bone but also destroys the continuity and integrity of bone and cannot completely remove the local tumor cells. The remaining tumor cells in the lesion bring a hidden danger of local recurrence. To improve the chemotherapeutic effect and effectively clear tumor cells, traditional systemic chemotherapy often requires higher doses, and high doses of chemotherapeutic drugs inevitably cause a series of systemic toxic side effects, often intolerable to patients. PLGA-based drug delivery systems, such as nano delivery systems and scaffold-based local delivery systems, can help eliminate tumors and promote bone regeneration and therefore have more significant potential for application in bone tumor treatment. In this review, we summarize the research progress of PLGA nano drug delivery systems and PLGA scaffold-based local delivery systems in bone tumor treatment applications, expecting to provide a theoretical basis for developing novel bone tumor treatment strategies.
摘要：
骨肿瘤已成为危害人类健康的常见病。手术切除骨肿瘤不仅造成骨的生物力学缺陷，而且破坏骨的连续性和完整性，不能完全清除局部肿瘤细胞。病灶中残留的肿瘤细胞带来了局部复发的隐患。提高化疗效果，有效清除肿瘤细胞，传统的全身化疗通常需要更高的剂量，高剂量化疗药物不可避免地会引起一系列全身毒副作用，患者往往无法忍受。基于PLGA的药物递送系统，如纳米递送系统和基于支架的局部递送系统，可以帮助消除肿瘤和促进骨再生，因此在骨肿瘤治疗中具有更大的应用潜力。在这次审查中,本文综述了PLGA纳米给药系统和PLGA支架局部给药系统在骨肿瘤治疗中的研究进展,以期为开发新的骨肿瘤治疗策略提供理论依据。
