Abstract:
The main question of this chapter is as follows: What is the contribution of changes in the sympathetic-respiratory coupling to the hypertension observed in some experimental models of hypoxia? Although there is evidence supporting the concept that sympathetic-respiratory coupling is increased in different models of experimental hypoxia [chronic intermittent hypoxia (CIH) and sustained hypoxia (SH)], it was also observed that in some strains of rats and in mice, these experimental models of hypoxia do not affect the sympathetic-respiratory coupling and the baseline arterial pressure. The data from studies performed in rats (different strains, male and female, and in the natural sleep cycle) and mice submitted to chronic CIH or SH are critically discussed. The main message from these studies performed in freely moving rodents and in the in situ working heart-brainstem preparation is that experimental hypoxia changes the respiratory pattern, which correlates with increased sympathetic activity and may explain the hypertension observed in male and female rats previously submitted to CIH or SH.
摘要:
本章的主要问题如下:在某些缺氧实验模型中观察到的交感神经-呼吸耦合的变化对高血压的贡献是什么?尽管有证据支持在不同的实验缺氧模型[慢性间歇性缺氧(CIH)和持续缺氧(SH)]中交感神经-呼吸耦合增加的概念,还观察到,在某些品系的大鼠和小鼠中,这些缺氧的实验模型不影响交感神经-呼吸耦合和基线动脉压.来自大鼠研究的数据(不同菌株,男性和女性,并且在自然睡眠周期中),并严格讨论了提交给chronicCIH或SH的小鼠。在自由移动的啮齿动物和原位工作的心-脑干准备中进行的这些研究的主要信息是,实验性缺氧会改变呼吸模式,这与交感神经活动增加相关,可以解释先前接受CIH或SH的雄性和雌性大鼠中观察到的高血压。