Abstract：
Carbon dots (CDs) are novel zero-dimensional spherical nanoparticles with water solubility, biocompatibility and photoluminescence properties. As the variety of raw materials for CDs synthesis becomes more and more abundant, people tend to choose precursors from nature. Many recent studies have shown that CDs can inherit properties similar to their carbon sources. Chinese herbal medicine has a variety of therapeutic effects to many diseases. In recent years, many literatures have chosen herbal medicine as raw materials, however, how the properties of raw materials affect CDs has not been systematically summarized. The intrinsic bioactivity and potential pharmacological effects of CDs have not received sufficient attention and have become a \'blind spot\' for research. In this paper, the main synthesis methods were introduced and the effects of carbon sources from different herbal medicine on the properties of CDs and related applications were reviewed. In addition, we briefly review some of the biosafety assessments of CDs, and make recommendations for biomedical applications. CDs that inherit the therapeutic properties of herbs can enable diagnosis and treatment of clinical diseases, bioimaging, and biosensing in the future.
摘要：
碳点（CD）是一种新型的具有水溶性的零维球形纳米颗粒，生物相容性和光致发光性能。随着碳点合成原料的种类越来越丰富,人们倾向于从自然中选择前体。最近的许多研究表明，CD可以继承与其碳源相似的特性。中草药对许多疾病有多种治疗作用。近年来,许多文献选择了草药作为原料，然而,原材料的性能如何影响CD尚未得到系统的总结。CD的内在生物活性和潜在药理作用尚未得到足够的重视，已成为研究的“盲点”。在本文中,介绍了主要的合成方法，综述了不同中草药碳源对Cd性质的影响及相关应用。此外,我们简要回顾了一些CD的生物安全性评估，并为生物医学应用提出了建议。继承草药治疗特性的CD可以诊断和治疗临床疾病，生物成像,和未来的生物传感。
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