PDF(Pubmed)
Abstract：
Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties. Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory drugs. The aim of this study was to investigate the antiulcer effect of felodipine on indomethacin-induced gastric ulcers in Wistar rats and compare it with that of famotidine. The antiulcer activities of felodipine (5 mg/kg) and famotidine were investigated biochemically and macroscopically in animals treated with felodipine (5 mg/kg) and famotidine in combination with indomethacin. The results were compared with those of the healthy control group and the group administered indomethacin alone. It was observed that felodipine suppressed the indomethacin-induced malondialdehyde increase (P<0.001); reduced the decrease in total glutathione amount (P<0.001), reduced the decrease superoxide dismutase (P<0.001), and catalase activities (P<0.001); and significantly inhibited ulcers (P<0.001) at the tested dose compared with indomethacin alone. Felodipine at a dose of 5 mg/kg reduced the indomethacin-induced decrease in cyclooxygenase-1 activity (P<0.001) but did not cause a significant reduction in the decrease in cyclooxygenase-2 activity. The antiulcer efficacy of felodipine was demonstrated in this experimental model. These data suggest that felodipine may be useful in the treatment of nonsteroidal anti-inflammatory drug-induced gastric injury.
摘要：
非洛地平是一种具有抗氧化和抗炎特性的钙通道阻滞剂。研究人员指出，氧化应激和炎症在非甾体抗炎药引起的胃溃疡的病理生理学中也起作用。这项研究的目的是研究非洛地平对吲哚美辛引起的Wistar大鼠胃溃疡的抗溃疡作用，并将其与法莫替丁进行比较。在用非洛地平（5mg/kg）和法莫替丁与吲哚美辛联合治疗的动物中，对非洛地平（5mg/kg）和法莫替丁的抗溃疡活性进行了生化和宏观研究。将结果与健康对照组和单独使用吲哚美辛的组进行比较。观察到非洛地平抑制了吲哚美辛诱导的丙二醛增加（P<0.001）；减少了总谷胱甘肽量的减少（P<0.001），降低超氧化物歧化酶的降低（P<0.001），和过氧化氢酶活性（P<0.001）；与单独的吲哚美辛相比，在测试剂量下显着抑制溃疡（P<0.001）。5mg/kg剂量的非洛地平可降低吲哚美辛诱导的环氧合酶-1活性降低（P<0.001），但未引起环氧合酶-2活性降低的显着降低。在该实验模型中证明了非洛地平的抗溃疡功效。这些数据表明，非洛地平可能可用于治疗非甾体抗炎药引起的胃损伤。
