Abstract：
Neonatal lupus erythematosus (NLE) is an uncommon disorder affecting approximately one out of 20 000 live births in the United States. Common manifestations of NLE include cutaneous eruptions and cardiac involvement. The typical rash of NLE most closely resembles the rash of subacute cutaneous lupus erythematosus both clinically and histopathologically. We present a case of reactive granulomatous dermatitis (RGD) associated with NLE in a 3-month-old male in whom the initial histopathology and immunohistochemistry were concerning for hematologic malignancy. RGD is a unifying term used to describe cutaneous granulomatous eruptions that occur in response to a variety of stimuli, including autoimmune connective tissue diseases. Our case demonstrates the range of histopathological findings that may be present in the setting of NLE.
摘要：
新生儿红斑狼疮（NLE）是一种罕见的疾病，在美国约有20,000名活产婴儿。NLE的常见表现包括皮肤爆发和心脏受累。NLE的典型皮疹在临床和组织病理学上最类似于亚急性皮肤红斑狼疮的皮疹。我们介绍了一名3个月大的男性与NLE相关的反应性肉芽肿性皮炎（RGD）病例，其中最初的组织病理学和免疫组织化学与血液恶性肿瘤有关。RGD是一个统一的术语，用于描述皮肤肉芽肿爆发，发生在各种刺激的反应，包括自身免疫性结缔组织疾病。我们的病例证明了NLE患者可能存在的组织病理学发现范围。
