Abstract：
Poly(vinyl alcohol) (PVA)-based hydrogels have attracted great attention and been widely used in biological tissue engineering. With the development of modern medicine, precision medicine requires the customization of medical materials. However, lacking of photocurable functional groups or the performance of rapid phase transition makes PVA-based hydrogels difficult to be customizable molded through photocuring 3D printing technique. In this research, customizable PVA-based hydrogels with high performance through 3D photocurable printing and freezing-thawing (F-T) process are obtained. The ability of 3D-printable is endowed by the introduction of polyvinyl alcohol-styrylpyridine (PVA-SBQ), which can be photo-crosslinked quickly without photoinitiator. Meanwhile, the tunable mechanical properties are achieved by adjusting the mass ratio of PVA-SBQ to PVA, and PVA can offer the physical crosslinking points through freezing-thawing (F-T) process. The hydrogels with high resolution are prepared by digital light procession 3D printing with the mass ratio 1:1 of PVA-SBQ to PVA solution. Attributed to the absence of initiator, and no small molecule residues inside the hydrogels, the hydrogels have good biocompatibility and have the potential to be applicated in the field of biological tissue engineering.
摘要：
聚乙烯醇(PVA)基水凝胶在生物组织工程中得到了广泛的应用。随着现代医学的发展,精准医疗需要定制医疗材料。然而,缺乏光固化官能团或快速相变的性能使得PVA基水凝胶难以通过光固化3D打印技术进行定制成型。在这项研究中,通过3D光固化打印和冻融（F-T）工艺获得了可定制的高性能PVA基水凝胶。通过引入聚乙烯醇-苯乙烯基吡啶（PVA-SBQ）赋予了3D打印能力，它可以在没有光引发剂的情况下快速光交联。同时,通过调整PVA-SBQ与PVA的质量比,和PVA可以通过冻融（F-T）过程提供物理交联点。采用PVA-SBQ与PVA溶液质量比为1:1的DLP3D打印方法制备高分辨率水凝胶。归因于没有发起者，水凝胶内没有小分子残留物，水凝胶具有良好的生物相容性，在生物组织工程领域具有广阔的应用前景。本文受版权保护。保留所有权利。
