Abstract：
The therapeutic effects and application of radiotherapy are restricted to some extent due to low radiosensitivity of tumor tissues and adverse effects by excess dosage. Current radiosensitizers are confronted with problems in clinical translation because of complicated manufacture technique and high cost. In this research, we have synthesized a radiosensitizer with advantages in low cost and mass production, which could be applied to CT imaging and enhanced radiotherapy in breast cancer, namely Bi-DTPA. It not only enhanced tumor CT imaging which resulted in better therapeutic accuracy, but also realized radiotherapy sensitization by producing massive ROS and inhibit tumor proliferation, providing a sound perspective in the clinical translation of the radiosensitizer.
摘要：
由于肿瘤组织的放射敏感性低和剂量过大的不良反应，放射治疗的疗效和应用受到一定程度的限制。当前的放射增敏剂由于制造技术复杂和成本高，在临床翻译中面临问题。在这项研究中,我们合成了一种具有低成本和批量生产优势的放射增敏剂，可以应用于乳腺癌的CT成像和增强放射治疗，即Bi-DTPA。它不仅增强了肿瘤CT成像，导致更好的治疗准确性，而且还通过产生大量的ROS和抑制肿瘤增殖来实现放疗敏化，在放射增敏剂的临床翻译中提供了良好的视角。
