Abstract：
A persistent epithelial defect (PED) is a corneal epithelial defect that failed to heal after 2weeks. It is a condition that carries much morbidity, and our understanding of PED remains poor, with current treatment methods often having unsatisfactory outcomes. With PEDs becoming more prevalent, more efforts are required to establish reliable treatment modalities. Our reviews describe the causes of PEDs and the different approaches developed to manage them, as well as their associated limitations. Emphasis is placed on understanding various advances in the development of new treatment modalities. We have also described a case of a woman with a background of graft-versus-host disease on long-term topical corticosteroids who developed complicated PED involving both eyes. The current approach to managing PEDs generally involves exclusion of an active infection, followed by treatment modalities that aim to encourage corneal epithelial healing. Success rates, however, remain far from desirable, as treatment remains challenging due to multiple underlying etiologies. In summary, advances in the development of new therapies may be able to facilitate progress in the understanding and treatment of PED.
摘要：
持续性上皮缺损(PED)是指2周后未能愈合的角膜上皮缺损。这是一种发病率很高的疾病，我们对PED的理解仍然很差，目前的治疗方法往往效果不理想。随着PED变得越来越普遍，需要更多的努力来建立可靠的治疗方式。我们的评论描述了PED的原因以及为管理它们而开发的不同方法，以及它们的相关限制。重点放在理解在开发新的治疗方式的各种进展。我们还描述了一个案例，该女性患有长期局部皮质类固醇的移植物抗宿主病（GVHD），并发展了涉及双眼的复杂PED。目前管理PED的方法通常包括排除活动性感染，其次是旨在促进角膜上皮愈合的治疗方式。成功率,然而,仍然远远不可取，由于多种潜在病因，治疗仍然具有挑战性。总之,新疗法开发的进展可能会促进PED的理解和治疗的进展。
