PDF(Pubmed)
Abstract：
We have previously reported that serum albumin-coated bone allograft (BoneAlbumin, BA) is an effective bone substitute. It improves bone regeneration at the patellar and tibial donor sites six months after harvesting bone-patellar tendon-bone (BPTB) autografts for primary anterior cruciate ligament reconstruction (ACLR). In the present study, we examined these donor sites seven years after implantation. The study group (N = 10) received BA-enhanced autologous cancellous bone at the tibial and BA alone at the patellar site. The control group (N = 16) received autologous cancellous bone at the tibial and blood clot at the patellar site. We evaluated subcortical density, cortical thickness, and bone defect volume via CT scans. At the patellar site, subcortical density was significantly higher in the BA group at both time points. There was no significant difference in cortical thickness between the two groups at either donor site. The control group\'s bone defect significantly improved and reached the BA group\'s values at both sites by year seven. Meanwhile, the bone defects in the BA group did not change significantly and were comparable to the six-month measurements. No complications were observed. There are two limitations in this study: The number of patients recruited is small, and the randomization of the patients could have improved the quality of the study as the control group patients were older compared to the study group patients. Our 7-year results seem to demonstrate that BA is a safe and effective bone substitute that supports faster regeneration of donor sites and results in good-quality bone tissue at the time of ACLR with BPTB autografts. However, studies with a larger number of patients are required to definitively confirm the preliminary results of our study.
摘要：
我们以前报道过血清白蛋白包被的同种异体骨移植(BoneAlbulmin，BA)是一种有效的骨替代物。在收获骨-髌腱-骨（BPTB）自体移植物进行原发性前交叉韧带重建（ACLR）后六个月，它可以改善髌骨和胫骨供体部位的骨再生。在本研究中,我们在植入7年后检查了这些供体部位.研究组（N=10）在胫骨处接受了BA增强的自体松质骨，在the骨部位仅接受了BA。对照组（N=16）在胫骨接受自体松质骨，在髌骨部位接受血凝块。我们评估了皮质下密度,皮质厚度,CT扫描的骨缺损量。在髌骨部位，在两个时间点，BA组的皮质下密度均显着较高。在任一供体部位，两组之间的皮质厚度均无显着差异。到第7年，对照组的骨缺损明显改善，并在两个部位均达到BA组的值。同时,BA组的骨缺损没有显著变化,与6个月的测量结果相当.未观察到并发症。这项研究有两个局限性：招募的患者数量很少，患者的随机化可以提高研究质量，因为对照组患者比研究组患者年龄更大。我们的7年结果似乎表明，BA是一种安全有效的骨替代品，可支持供体部位的更快再生，并在使用BPTB自体移植物进行ACLR时产生优质的骨组织。然而,需要对更多患者进行研究以明确确认我们研究的初步结果.
